Publications by authors named "Jai Jai Shankar"
Rationale: Clinical outcomes in acute ischemic stroke due to medium vessel occlusion (MeVO) are often poor when treated with best medical management. Data from non-randomized studies suggest that endovascular treatment (EVT) may improve outcomes in MeVO stroke, but randomized data on potential benefits and risks are hitherto lacking. Thus, there is insufficient evidence to guide EVT decision-making in MeVO stroke.
View Article and Find Full Text PDFBackground: The AcT (Alteplase Compared to Tenecteplase) randomized controlled trial showed that tenecteplase is noninferior to alteplase in treating patients with acute ischemic stroke within 4.5 hours of symptom onset. The effect of time to treatment on clinical outcomes with alteplase is well known; however, the nature of this relationship is yet to be described with tenecteplase.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates whether tenecteplase, an alternative to alteplase, is equally safe and effective for treating patients with acute ischemic stroke caused by large vessel occlusion (LVO).
- Conducted as part of the ACT trial in Canada, this analysis involved 1,600 patients with disabling strokes enrolled from 22 stroke centers over a span of two years, where they were randomly assigned to receive either medication.
- The primary outcome measured was the likelihood of achieving a modified Rankin scale score of 0-1 at 90 days, with secondary outcomes including mortality rates, rates of symptomatic intracerebral hemorrhage, and successful reperfusion rates.
Purpose: The goal of this study was to understand the impact of COVID-19 pandemic and associated lockdown measures on the volume, rate, and type of trauma presenting to the emergency department (ED) by using trauma-initiated CT studies to capture patient data.
Materials And Methods: We performed a retrospective observational study comparing patients undergoing CT scans for trauma during the 1 and 2 lockdown periods compared to corresponding prepandemic months. During two lockdown periods, public places such as restaurants, libraries, parks, and shops across the province were shut down.