Nanoapatite-Loaded κ-Carrageenan/Poly(vinyl alcohol)-Based Injectable Cryogel for Hemostasis and Wound Healing.

Immediate control of excessive bleeding and prevention of infections are of utmost importance in the management of wounds. Cryogels have emerged as promising materials for the rapid release of medication and achieving hemostasis. However, their quick release properties pose the challenge of exposing patients to high concentrations of drugs.

Facile synthesis of mixed O, S or Se bearing hexasubstituted benzenes and their potential as Cu(ii) ion probe.

The present study offers a facile route for the synthesis of unsymmetrical hexasubstituted benzenes bearing alternate heteroatoms (O, S and Se) with the formula [1,3,5-(RSeCH2)3-2,4,6-(R'ECH2)3C6] (E = O, S or Se). The synthetic protocol involves the use of an in situ generated tris(selenonium) ion followed by treatment with another nucleophile affording the targeted species in >70% yields. The unsymmetrical hexasubstituted derivatives were characterized on the basis of physicochemical and spectroscopic data and in a representative case with single crystal X-ray study.

En Route Activity of Hydration Water Allied with Uranyl (UO) Salts Amid Complexation Reactions with an Organothio-Based (O, N, S) Donor Base.

This study provides en route activity of hydration water allied with uranyl salts amid complexation reactions with a donor species L bearing O, N, and S (phenolic, -OH; imine, -HC═N-; and thio-, -S-) donor functionalities. The UO/L reaction encounters a series of hydrolytic steps with hydration water released from uranyl salts during the complexation processes. Primarily, the coordinated [L → UO(NO)/(OAc)] species formed during the complexation process undergoes partial hydrolysis of the coordinated ligand resulting in the isolation of an aldehyde coordinated uranyl species [L → UO(NO)/(OAc)].

Synthesis and preliminary biological evaluation for the anticancer activity of organochalcogen (S/se) tethered chrysin-based organometallic Ru(η-p-cymene) complexes.

Organochalcogen (S/Se) functionalized chrysin derivatives were synthesized and coordinated with Ru(--cymene) to efficiently form ruthenium-based chemotherapeutic drug entities [CHOSRuCl]; [CHOSeRuCl]; [CHOSRuCl]; and [CHOSeRuCl]. The complexes were thoroughly characterized by analytical and various spectroscopic techniques which include elemental analysis, UV-vis, IR, NMR (H, C, and Se NMR), and HR-MS. The interaction studies of these Ru(II) complexes were carried out with CT DNA/HSA by employing UV-vis, fluorescence and circular dichroic techniques in view to examine their chemotherapeutic potential.

Responsive nature of 1,2,4,5-tetrakis(2-pyridylthiomethyl)benzene toward group 12 metal nitrates: activity of coordinated nitrate in metal complexes.

This study provides a detailed analysis on the responsive behavior of 1,2,4,5-tetrakis(2-pyridylthiomethyl)benzene (L) toward group 12 metal nitrates in both aqueous and nonaqueous media. The ligand L proved to be an environmentally responsive species, and structural investigations of its complexes with respective M(NO3)2 (M = Zn, Cd, and Hg) allowed one to remark on the inherent activity of the nitrate ion, resulting in a distinctively higher coordination number and dimensionality to the metal cations.

An organoselenium-based highly sensitive and selective fluorescent "turn-on" probe for the Hg2+ ion.

An organoselenium-based NSe(3) type of tripodal system 2 as a Hg(2+)-selective fluorescence "turn-on" probe is described. The "turn-on" fluorescence behavior of this selenotripod 2 is significant because it depends on Hg-Se bond formation and acts as a reporting unit for this system. The system exhibits immediate response (15 s) with a subnanomolar detection limit (0.