LPAR3 and COL8A1, as matrix stiffness-related biomarkers, promote nasopharyngeal carcinoma metastasis by triggering EMT and angiogenesis.

Matrix stiffness affects the progression of nasopharyngeal carcinoma, but the underlying mechanism is still unknown. Here, we demonstrated that nasopharyngeal carcinoma tissues with distant metastasis contain large collagen deposits and strong matrix stiffness. First, we performed RNA-seq analysis of nasopharyngeal carcinoma cells cultured on polyacrylamide hydrogel systems and found that LPAR3 and COL8A1 are potential matrix stiffness markers.

Serum CircCSPP1 is Correlated with the Occurrence and Severity of NAFLD in a Chinese Population.

The relationship between serum circCSPP1, circNIPSNAP3A, or circRFX8 and the occurrence and severity of non-alcoholic fatty liver disease (NAFLD) has yet to be fully elucidated. A total of 494 participants were divided into NAFLD and control groups, and clinical data, including demographic, physiological and biochemical parameters, were collected. Serum levels of circCSPP1, circNIPSNAP3A, and circRFX8 were measured using quantitative real-time PCR, and the severity of NAFLD was assessed by ultrasonography and quantitative computed tomography.

Integrating untargeted/targeted metabolomics and network pharmacology association analysis to study the mechanism of safflower regulating C18:0 sphingolipid metabolism to treat acute myocardial ischemia.

Background: Safflower extract (SE) has been reported to treat acute myocardial ischemia (AMI); however, its underlying mechanism remains unclear.

Purpose: To investigate the ameliorative effects of SE on rats with AMI and the underlying mechanism.

Methods: UPLC-Q-TOF-MS/MS method was used to analyze the drug-derived components in the serum of rats following SE administration.

The efficacy of ICIs rechallenge in advanced small cell lung cancer after progression from ICIs plus chemotherapy: A real-world study.

Background: Rechallenging immune checkpoint inhibitors(ICIs) after resistance to initial ICIs plus chemotherapy(chemo-ICIs) remains uncertain in advanced small cell lung cancer(SCLC).

Method: The study retrospectively enrolled advanced SCLC patients who received ICIs after developing resistance to chemo-ICIs during hospitalization at Hunan Cancer Hospital from January 2020 to November 2023. The clinical outcomes and prognosis factors for ICIs rechallenge were further analyzed.

The role of VEGF in Cancer angiogenesis and tumorigenesis: Insights for anti-VEGF therapy.

Vascular endothelial growth factor (VEGF) is a critical regulator of angiogenesis, playing a pivotal role in both physiological and pathological processes. It promotes the formation of new blood vessels and activates downstream signaling pathways that regulate endothelial cell function. This review highlights recent advancements in the understanding of VEGF's molecular structure and its isoforms, as well as their implications in disease progression.

Thermosonication enhanced the bioactive, antioxidant, and flavor attributes of freshly squeezed tomato juice.

The sterilization of freshly squeezed juices typically results in a compromise to the natural flavor, bio-active components, and nutritional value. Developing a new sterilization method for controlling the diverse effects has emerged as a significant challenge. This research aims to explore the potential application of thermosonication (TS) for freshly squeezed tomato juice.

Global research landscape and trends in Toxoplasma gondii from 2003 to 2022: A bibliometric analysis.

Toxoplasmosis is a globally prevalent zoonotic disease with significant public health impact, yet effective prevention and control measures remain lacking. This study analyzed 10,737 publications from 2003 to 2022 in the Web of Science and Scopus databases using bibliometric methods. Key metrics, including annual publication trends, journals, core authors, contributing countries, citations, and keywords, were examined.

Cellular blueprint of healthy and diseased human epiglottis and subglottis-a study of the Canadian Airways Research (CARE) group.

Background: The larynx consists of the supraglottis, glottis, and subglottis and each differ in tissue composition, lymphatic drainage, ability to counter infections, and response to injuries. However, the cellular mechanisms driving laryngeal homoeostasis remain largely unexplored. As a result, understanding disease pathogenesis within the larynx including idiopathic subglottic stenosis (iSGS) and intubation-related traumatic stenosis has been challenging.

Cohort-level clinical trajectory and molecular landscape of idiopathic subglottic stenosis for precision laryngology-a study of the Canadian airways research (CARE) group.

Background: First described in 1972, idiopathic subglottic stenosis (iSGS) is a serious chronic orphan disease characterised by recurrent scarring of the subglottis. Although the cause is unknown, iSGS is almost exclusively restricted to Caucasian females typically in their fourth to sixth decade. However, given its rare incidence (1:400,000), understanding the clinical trajectory and molecular factors associated with iSGS disease development and prognosis has been difficult.

Rotenone-driven DNA hypermethylation of the miR-6991-3p promoter induces death of mouse brain organoids.

Rotenone has potential chemical toxicity in the nervous system of both insects and mammals, but its deep molecular biological mechanisms have not been clarified. Here, the epigenetic regulatory mechanism underlying the toxicity of rotenone was studied using murine brain organoids (mBOs). Transmission electron microscopy indicated that rotenone destroyed mBOs'mitochondrial structure.

Decoding Allergenicity Modulation in Cold Argon Plasma-Treated Casein: A Multi-Omics Exploration.

Cold argon plasma (CAP) effectively modifies casein (CN) structures by cleaving peptide chains and altering allergenic epitopes. This study assessed the allergenicity of CAP-treated CN in KU812 cells and BALB/c mouse models, supported by a multiomics approach integrating 16S rDNA sequencing, serum metabolomics, and jejunal transcriptomics. CAP treatment reduced CN allergenicity, evidenced by decreased KU812 cell degranulation, alleviated allergic responses in mice, and a Th1/Th2 balance shift toward Th1 dominance.

Protocol for processing multivariate time-series electronic health records of COVID-19 patients.

The lack of standardized techniques for processing complex health data from COVID-19 patients hinders the development of accurate predictive models in healthcare. To address this, we present a protocol for utilizing real-world multivariate time-series electronic health records of COVID-19 patients. We describe steps for covering the necessary setup, data standardization, and formatting.

The integration of health equity into policy to reduce disparities: Lessons from California during the COVID-19 pandemic.

Racial and ethnic minoritized groups and socioeconomically disadvantaged communities experience longstanding health-related disparities in the United States and were disproportionately affected throughout the COVID-19 pandemic. How departments of public health can explicitly address these disparities and their underlying determinants remains less understood. To inform future public health responses, this paper details how California strategically placed health equity at the core of its COVID-19 reopening and response policy, known as the Blueprint for a Safer Economy.

Association of oxidative balance score with incident cardiovascular disease in patients with type 2 diabetes: findings of the UK Biobank study.

Background & Aims: To clarify how dietary and lifestyle factors work on diabetes-related cardiovascular disease (CVD), we investigated whether the increased risk of CVD in patients with type 2 diabetes mellitus (T2DM) could be offset by an increase in diet and/or lifestyle with antioxidant potential.

Research Design And Methods: A total of 7,658 individuals from UK Biobank (UKB) with T2DM but no diagnosed CVD were included in this study. We screened combinations of 16 nutrients and/or 4 lifestyles to calculate the Oxidative Balance Score (OBS), dietary OBS (DOBS), and lifestyle OBS (LOBS).

Study on the Electro-Fenton Chemomechanical Removal Behavior in Single-Crystal GaN Pin-Disk Friction Wear Experiments.

Electro-Fenton chemical mechanical polishing primarily regulates the generation of hydroxyl radicals (·OH) via the Fenton reaction through an applied electric field, which subsequently influences the formation and removal of the oxide layer on the workpiece surface, thereby impacting the overall polishing quality and rate. This study employs Pin-Disk friction and wear experiments to investigate the material removal behavior of single-crystal GaN during electro-Fenton chemical mechanical polishing. Utilizing a range of analytical techniques, including coefficient of friction (COF) curves, surface morphology assessments, cross-sectional analysis, and power spectral density (PSD) measurements on the workpiece surface, we examine the influence of abrasives, polishing pads, polishing pressure, and other parameters on the electro-Fenton chemical-mechanical material removal process.

Tuning charge transportation balance in quantum dot light emitting diodes by decreasing the mobility and conductivity of In-doped SnO nanocrystal electron transport layers.

The use of quantum sized SnO nanocrystals as the electron transportation layer (ETL) in quantum dot light-emitting diodes (QLEDs) has been demonstrated to be an effective method for improving device stability and eliminating the positive aging effect. However, compared to the commonly used 4,4'-bis(-carbazolyl)-1,1'-biphenyl (CBP) hole transportation layer (HTL), the quantum sized SnO nanocrystals usually possess a higher electron mobility and a higher conductivity, which results in the charge transport imbalance in QLEDs. Herein, In-doped SnO quantum-sized nanocrystals are synthesized by the ligand-assisted solvothermal method.

Three Cases of Borates with Different Dimensional Frameworks Induced by Metal Cations.

Three new metal borates containing d cations, namely, LiPbZnBO, NaCdBO and KSrZnBO(CO), were synthesized using the flux method. KSrZnBO(CO) is the first Zn-containing borate carbonate and has an unprecedented fundamental building block, [BO]. Furthermore, experimental and first-principles theoretical studies were performed.

A Knowledge-Guided Graph Learning Approach Bridging Phenotype- and Target-Based Drug Discovery.

Discovering therapeutic molecules requires the integration of both phenotype-based drug discovery (PDD) and target-based drug discovery (TDD). However, this integration remains challenging due to the inherent heterogeneity, noise, and bias present in biomedical data. In this study, Knowledge-Guided Drug Relational Predictor (KGDRP), a graph representation learning approach is developed that effectively integrates multimodal biomedical data, including network data containing biological system information, gene expression data, and sequence data that incorporates chemical molecular structures, all within a heterogeneous graph (HG) structure.

Porous Aromatic Framework with Multifunctional Sites for Effective Recovery of Various Trace Iodine Species From Water.

Recovery of environmental iodine is of great significance for both recycling iodine resources and addressing iodine pollution. However, iodine is highly sensitive to environmental factors and exists in various chemical species, which complicates the recovery of trace iodine in aqueous systems. Here a porous aromatic framework (iPAF-TEPT) is presented with multifunctional adsorption sites for efficient recovery of various iodine species, including molecular iodine (I), iodide (I and I ).

Comprehensive analysis of the transcriptomics and metabolomics reveal the changes induced by nano-selenium and melatonin in Zizyphus jujuba Mill. cv. Huizao.

Background: Jujube (Zizyphus jujuba), belonging to the Rhamnaceae, contains various bioactive components including flavonoids and polysaccharides. In our previous study, jujube quality was improved by application of nano-selenium (Nano-Se) and melatonin; however, little research has been conducted on the induced molecular mechanisms. Zizyphus jujuba cv.

Cascade-Type Microglial Pyroptosis Inhibitors for Enhanced Treatment of Cerebral Ischemia-Reperfusion Injury.

Neuroinflammation is a critical factor in the progression of cerebral ischemia-reperfusion injury (CIRI). Pyroptosis, which is an inflammatory form of programmed cell death, greatly amplifies neuroinflammatory processes. It does so by promoting the release of various inflammatory contents that intensify the overall inflammatory response within the central nervous system.

Advancements in extracellular vesicles biomanufacturing: a comprehensive overview of large-scale production and clinical research.

Extracellular vesicles (EVs) are nano-sized, membranous structures secreted by cells into the extracellular space, have attracted considerable attention in the field of biosciences for their role in intercellular communication in various physiological and pathological processes. Their ubiquitous presence in bodily fluids and cell-specific characteristics make them promising candidates as biomarkers. Additionally, their ability to transport biological therapeutics across different biological barriers to specific target cells underscores their significant translational potential for diagnostic and therapeutic purposes.

New options for cilostazol-based dual antiplatelet therapy for ischaemic stroke prevention in East Asian populations: a systematic review and meta-analysis.

Background And Purpose: The objective of this study is to systematically review the efficacy and safety of cilostazol-based dual antiplatelet therapy (DAPT) in patients with stroke.

Methods: Two reviewers conducted a comprehensive search of eligible studies published in PubMed, Medline, the Cochrane Library, Embase, and four Chinese databases from their establishment to 31 July 2024. The review was registered (CRD42024559047).

Leapfrogging : harnessing 1432 GPUs for 7× faster quantum random circuit sampling.

Random quantum circuit sampling serves as a benchmark to demonstrate quantum computational advantage. Recent progress in classical algorithms, especially those based on tensor network methods, has significantly reduced the classical simulation time and challenged the claim of first-generation quantum advantage experiments. However, in terms of generating uncorrelated samples, time to solution and energy consumption, previous classical simulation experiments still underperform the processor.