One way to deliver a drug and control its release is to use magnetic nanoparticles as drug carriers and conduct them by a magnetic field. In this method, drugs and magnetic nanoparticles (usually based on iron, nickel, cobalt or their oxides) are designed and prepared in a combination and injected into the bloodstream upstream of the tissue. These nanoparticles move through the bloodstream and approach the magnetic field.
View Article and Find Full Text PDFAtherosclerosis in the coronary arteries is one of the leading causes of death in the world. Percutaneous coronary interventions (PCI) associated with the implantation of drug eluting stents (DES) is one of the most common forms of revascularization in patients with atherosclerotic coronary artery disease. The use of DES is considered as an effective tool to reduce restenosis after PCI.
View Article and Find Full Text PDFComput Biol Med
November 2017
Atherosclerosis in the coronary artery is one of the leading causes of death in the world. The stenting as a minimally invasive technique was considered as an effective tool to reduce the severity of atherosclerotic stenosis. In-stent restenosis is the main drawback of the stenting in the coronary artery.
View Article and Find Full Text PDFIn this paper the effect of plaque composition, on the accumulation of drug released by a drug eluting stent, is analyzed. The mathematical model is represented by two coupled systems of partial differential equations that describe the pharmacokinetics of drug in the stent coating and in the arterial wall. The influence of the stiffness and porosity of soft and hard plaques is studied.
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