A New High Affinity Hemoglobin Variant: Hb San Francisco-KP (: c.104T>C).

The evaluation of erythrocytosis can fail to detect hemoglobin (Hb) variants if a thorough and systemic investigation is not undertaken. Here we report the identification of a novel high-oxygen affinity Hb that was previously misclassified as polycythemia vera (PV). Given that treatment recommendations can vary significantly based on the etiology of erythrocytosis, familiarity with reference laboratories and their methodologies is of crucial importance to conducting a precise consultation, as in the case of our Hb variant, named Hb San Francisco-KP [β34(B16)Val→Ala, : c.

Possible Precipitation of Acute Coronary Syndrome with Immune Checkpoint Blockade: A Case Report.

Introduction: Immune checkpoint inhibitors (ICI) have led to improved survival in patients with a number of different tumor types. The ICI agent nivolumab induces anti-tumor immune responses by inhibiting the programmed cell death 1 protein, but side effects include cardiac immune-related adverse events (irAE) such as myocarditis.¹ The association of nivolumab with atherosclerotic disease has been rarely reported.

Association of anticoagulation use with SARS-CoV2 detection.

• Patients who warrant chronic warfarin can safely continue warfarin therapy with precautions during the COVID-19 pandemic. • Chronic warfarin therapy is not associated with a higher rate of positively testing for SAR-CoV2. • Patients on warfarin during the COVID-19 pandemic maintained TTR rates consistent with those prior to the COVID-19 pandemic.

Mechanisms of drug resistance to vascular endothelial growth factor (VEGF) inhibitors.

Angiogenesis inhibitors have a major role in the treatment of varying cancers today. While originally thought to be independent of resistance, increasing data suggests varying mechanisms that bring about drug resistance, either intrinsically or through adaptation. The role of vascular endothelial growth factor single nucleotide polymorphisms (VEGF SNPs) in terms of therapeutic response and toxicity has increasingly been recognized, as well as its potential for contributing to drug resistance.