Publications by authors named "Jagreeti Singh"
Objectives: SETDB1 is a methyltransferase responsible for the methylation of histone H3-lysine-9, which is mainly related to heterochromatin formation. SETDB1 is overexpressed in various cancer types and is associated with an aggressive phenotype. In agreement with its activity, it mainly exhibits a nuclear localization; however, in several cell types a cytoplasmic localization was reported.
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- - Diabetes is a serious condition marked by high blood sugar levels, and traditional herbal treatments from Northeast India may help manage it, but need scientific backing for effectiveness.
- - The study focuses on analyzing a polyherbal formulation using advanced techniques like FT-IR and HR-LC/MS to identify its phytochemical makeup and assess its pharmacological properties.
- - Results show the formulation contains beneficial compounds like alkaloids, phenols, and flavonoids, with potential for good oral bioavailability and drug-like properties, indicating it may be effective for diabetes management.
Incessant production, pervasive applications in different fields, and eventually unintended exposure of cobalt oxide nanoparticles (Co3O4 NPs) lead to rise in their toxicity studies toward human health. However, the information regarding the potential toxicity mechanisms of Co3O4 NPs especially genotoxicity is still sparse with missing interconnections. So far, only solitary reports on Co3O4 NPs are at hand, bearing witness to reactive oxygen species (ROS)-mediated DNA damage in lung cells.
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