Publications by authors named "Jagoda Mika"
Article Synopsis
- - Weeds are valuable for research because they affect agriculture and can quickly adapt to changes caused by human activities.
- - A shortage of genomic data limits the understanding of how weeds rapidly adapt, especially regarding traits like resistance to herbicides and stress tolerance.
- - The International Weed Genomics Consortium aims to create genomic resources that enhance weed control research and support crop breeding by providing insights into adaptation and stress tolerance.
Deregulation of the EVI1 proto-oncogene by the GATA2 distal hematopoietic enhancer (G2DHE) is a key event in high-risk acute myeloid leukemia carrying 3q21q26 aberrations (3q-AML). Upon chromosomal rearrangement, G2DHE acquires characteristics of a super-enhancer and causes overexpression of EVI1 at 3q26.2.
View Article and Find Full Text PDFChordomas are rare bone tumors with few therapeutic options. Here we show, using whole-exome and genome sequencing within a precision oncology program, that advanced chordomas (n = 11) may be characterized by genomic patterns indicative of defective homologous recombination (HR) DNA repair and alterations affecting HR-related genes, including, for example, deletions and pathogenic germline variants of BRCA2, NBN, and CHEK2. A mutational signature associated with HR deficiency was significantly enriched in 72.
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