Enhanced Recovery Canada Clinical Pathway for Cesarean Delivery.

Enhanced recovery after surgery is a process to promote optimal recovery after a variety of operations utilized by many surgical specialties. This evidence-based series of interventions was developed to decrease the physiological stress and risks associated with surgery. In April of 2023, Enhanced Recovery Canada released its new Clinical Pathway for Cesarean Delivery.

Trapping and bypassing of suspended particulate matter, particulate nutrients and faecal indicator organisms in the river-estuary transition zone of a shallow macrotidal estuary.

Hydrodynamic controls of the transport of suspended particulate matter (SPM), particulate nutrients and faecal indicator organisms (FIOs) in the river-estuary transition zone (RETZ) of a shallow macrotidal estuary were studied on tidal and seasonal timescales. The RETZ was found to be a conduit for SPM rather than a zone of particle accumulation during spring tides, with complex size fractionation and biogeochemical exchanges of particulate nutrient/FIO compositions. The downstream RETZ was characterised by flood-dominant currents, but with ebb-dominant turbulence due to the suppression of flood tide turbulence by salinity stratification created by lateral convergence; this produced a net seaward mass transport of SPM.

Stepwise approach to the laparoscopic excision of bladder endometriosis.

Objective: To describe a stepwise approach to the laparoscopic excision of bladder endometriosis.

Design: Narrated surgical video.

Setting: Academic tertiary care hospital.

Outcomes of enhanced recovery after surgery (ERAS) in gynecologic oncology - A systematic review and meta-analysis.

Objective: To assess the benefit of Enhanced Recovery After Surgery (ERAS) on length of stay (LOS), postoperative complications, 30-day readmission, and cost in gynecologic oncology.

Methods: A systematic literature search was performed in MEDLINE, EMBASE, Cochrane Register of Controlled Trials, and Web of Science for all peer-reviewed cohort studies and controlled trials on ERAS involving gynecologic oncology patients. Abstracts, commentaries, non-controlled studies, and studies without specific data on gynecologic oncology patients were excluded.

Trustworthiness and Ideological Similarity (But Not Ideology) Promote Empathy.

The current highly polarized U.S. political culture impedes people's ability to live and work together effectively.

Laparoscopic excision of pericardial and diaphragmatic endometriosis.

Objective: To present a five-step approach to the laparoscopic excision of pericardial and diaphragmatic endometriosis.

Design: Surgical video.

Setting: Academic tertiary care hospital.

Bowel surgery for endometriosis: A practical look at short- and long-term complications.

Endometriosis involving the bowel requires a thorough evaluation prior to deciding upon surgical treatment. Patient symptoms, treatment goals, extent and location of disease, surgeon experience, and anticipated risks all play a part in the preoperative decision-making process. Short- and long-term complications after bowel surgery for endometriosis are the focus of this article.

Coronavirus Disease 2019 (COVID-19) and Pregnancy: Combating Isolation to Improve Outcomes.

With the current global coronavirus disease 2019 (COVID-19) pandemic, new challenges arise as social distancing and isolation have become the standard for safety. Evidence supports the protective benefits of social connections and support during pregnancy and labor; there are increased maternal, fetal, and pregnancy risks when pregnant and laboring women lack support. As health care professionals take appropriate precautions to protect patients and themselves from infection, there must be a balance to ensure that we do not neglect the importance of social and emotional support during important milestones such as pregnancy and childbirth.

Checkpoint inhibitors: a cutting edge in oncology.

The checkpoint inhibitor field, and indeed the whole of immuno-oncology, is fast-paced and fascinating, with huge clinical and commercial potential. The challenge in the coming years will be to define the best type and combination of immunotherapy, and the best target population to receive it. Keytruda's ground-breaking approval for a biomarker-based rather than location-based indication is a solid step in this direction, and is likely to be followed by other such approvals.

Decay rates of faecal indicator bacteria from sewage and ovine faeces in brackish and freshwater microcosms with contrasting suspended particulate matter concentrations.

To safeguard human health, legislative measures require the monitoring of faecal indicator bacteria (FIB) concentrations in recreational and shellfish waters. Consequently, numerous studies have focussed on FIB survival in the water column and more recently in estuarine sediments. However, there is a paucity of information regarding the influence of contrasting suspended particulate matter (SPM) concentrations on the survival of FIB in the water column of estuaries.

Progesterone and HMOX-1 promote fetal growth by CD8+ T cell modulation.

Intrauterine growth restriction (IUGR) affects up to 10% of pregnancies in Western societies. IUGR is a strong predictor of reduced short-term neonatal survival and impairs long-term health in children. Placental insufficiency is often associated with IUGR; however, the molecular mechanisms involved in the pathogenesis of placental insufficiency and IUGR are largely unknown.

Sediment composition influences spatial variation in the abundance of human pathogen indicator bacteria within an estuarine environment.

Faecal contamination of estuarine and coastal waters can pose a risk to human health, particularly in areas used for shellfish production or recreation. Routine microbiological water quality testing highlights areas of faecal indicator bacteria (FIB) contamination within the water column, but fails to consider the abundance of FIB in sediments, which under certain hydrodynamic conditions can become resuspended. Sediments can enhance the survival of FIB in estuarine environments, but the influence of sediment composition on the ecology and abundance of FIB is poorly understood.

The interaction of human microbial pathogens, particulate material and nutrients in estuarine environments and their impacts on recreational and shellfish waters.

Anthropogenic activities have increased the load of faecal bacteria, pathogenic viruses and nutrients in rivers, estuaries and coastal areas through point and diffuse sources such as sewage discharges and agricultural runoff. These areas are used by humans for both commercial and recreational activities and are therefore protected by a range of European Directives. If water quality declines in these zones, significant economic losses can occur.

Spotlight on depression: a Pharma Matters report.

Depression represents a huge pharmaceutical market opportunity. There are approximately 350 million people worldwide with depression, and it is the leading cause of disability in the world. In the U.

2012 in review - part II: overcoming the obstacles in the pharma/biotech industry.

As highlighted in the first part of this review published last month, the year 2012 saw the approval of a remarkable number of new drugs, and among the new drugs reaching the market, a significant proportion were orphan drugs developed for treating less prevalent diseases. These drugs are certainly not expected to become blockbusters, but are of high interest because of their efficacy in a narrow spectrum of patients. This trend aligns with the general tendency of staying away from fit-for-all blockbusters into personalized medicine as one of the strategies for overcoming the patent cliff that resulted in a long list of drugs going off patent and being approved as generics also during last year.

Fostering new investigators in Reproductive Immunology.

During the 8th European Congress of Reproductive Immunology, November 2010 in Munich, Germany, the European Society of Reproductive Immunology provided the opportunity for young investigators to present their work. Short talks from students and post-doctoral trainees were scheduled immediately after the keynote speakers in each session. The Society presented two "Young Investigator Awards" in basic science as well as in clinical application, sponsored by Elsevier.

Highway to health; or How prenatal factors determine disease risks in the later life of the offspring.

Fetal development is largely dependent on the mother. However, pregnancy maintenance and consequently fetal development are highly vulnerable and sensitive to disruption, triggered by, for example, prenatal stress challenge. Such prenatal stress challenge modulates the maternal endocrine and immune responses during pregnancy e.

SMi's Conducting Clinical Trials in Europe.

The Conducting Clinical Trials in Europe meeting, held in London, included topics covering new developments in the field of clinical trials and recommendations on how to best conduct a trial. This conference report highlights selected presentations on the state of affairs of trials in Europe, conducting trials in emerging markets, strategies for improving trials, trial design options, peri-approval and pediatric trials, and the role of key players, such as physicians. Company perspectives from Pfizer Inc and Nycomed are also included.

Aspirin modified dendritic cells are potent inducers of allo-specific regulatory T-cells.

Salicylic acid (aspirin) is a widely used pharmacological agent with immunodmodulatory properties. Dendritic cells are key regulators of the immune response, and are capable of inducing hyporesponsiveness and regulatory activity in CD4+ T-cells. We have demonstrated that aspirin-treated dendritic cells are effective at antigen processing and presentation, and possess a unique potency for inducing regulatory activity in responder T-cells.