Publications by authors named "Jagnehswar Dandapat"
The current communication reports the inhibitory effect of para-benzoquinone (p-BQ) on the structure and function of bovine liver catalase (BLC), a vital antioxidant enzyme. Both BLC and p-BQ were dissolved in respective buffers and the biophysical interaction was studied at physiological concentrations. For the first time our data reveals an enthalpy-driven interaction between BLC and p-BQ which is due to hydrogen bonding and van der Waals interactions.
View Article and Find Full Text PDFBackground: Cervical cancer is one of the most common gynaecological malignant tumors reported in women. Although a number of early screening and treatment options are available, mortality due to cervical cancer remains high. Nerium oleander L.
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- Alzheimer's disease (AD) is a complex neurodegenerative disorder that affects memory and cognitive functions, with existing FDA-approved treatments only providing symptomatic relief rather than a cure.
- Various traditional and ethnobotanical sources, including plants used in Indian, Chinese, and European medicine, show promise in developing new AD therapies, while the overexploitation of specific medicinal plants has inspired the creation of synthetic drugs like rivastigmine and new prodrugs.
- The article emphasizes the need for a shift from a "one-molecule-one-target" approach to a "combination-drugs-multi-targets" strategy that addresses the multiple underlying factors of AD, along with exploring various biological sources for potential therapeutic agents.