Persistent chronic inflammation and infection by Chikungunya arthritogenic alphavirus in spite of a robust host immune response.

Alphaviruses, including Chikungunya virus (CHIKV), produce a transient illness in humans, but severe forms leading to chronic incapacitating arthralgia/arthritis have been reported by mechanisms largely ill-characterized. The pathogenesis of CHIKV was addressed in a prospective cohort study of 49 hospitalized patients from Reunion Island subsequently categorized into two distinct groups at 12 mo postinfection. Comprehensive analyses of the clinical and immunological parameters throughout the disease course were analyzed in either the "recovered" or the "chronic" groups to identify prognostic markers of arthritis-like pathology after CHIKV disease.

[Composite nail transfer by the traditional method].

Introduction: We have retrospectively reviewed our experience in the treatment of traumatic loss of the whole nail complex.

Method: Contraindications for our technique are cases suitable for microsurgical transfer and cases with a poorly vascularised recipient bed. Under local anaesthesia, we harvested the nail unit composed of the eponychiurn matrix, nail table, hyponychium and lateral folds.

[Long-term results of Insall's total condylar knee prosthesis (10-to-13-year follow-up)].

We have studied 10 to 13 years postoperatively the first 105 total knee arthroplasties using the Total Condylar, a semiconstrained prosthesis with sacrifice of the cruciate ligaments, inserted between 1979 and 1983, in 99 patients (6 were bilateral). The average age of these patients was 73.5 years at the time of arthroplasty.

[Posterior luxation of the tibia on total knee prosthesis: apropos of 6 cases].

Purpose Of The Study: Posterior dislocation of Total knee arthroplasty is an infrequent but serious complication. Six cases of this complication were treated from 1979 to december 1993, all occurring on primary arthroplasties.

Material And Methods: Knee arthroplasty was performed once for rheumatoid arthritis, five times for osteoarthritis.

[Long-term result of lumbar disk chemonucleolysis (a 8-12 years follow-up)].

Introduction: This study is an attempt to assess the effects of chemonucleolysis over an extended period of time (8 to 12 years follow-up).

Material And Methods: From 1981 to 1985, chemonucleolysis using Chymopapain was performed on 134 patients for the relief of radicular pain from herniated lumbar discs. The long term results were evaluated in 110 patients.