Publications by authors named "Jaffar Raza"

Background: Fanconi anemia is an inherited bone marrow failure syndrome characterized by somatic abnormalities and an increased predisposition to malignancies.

Objective: To determine the clinical spectrum and evaluate the hematological parameters as well as highlight diagnosis by chromosomal breakage analysis of Fanconi anemia patients.

Material And Methods: A total of 124 patients were diagnosed as having Fanconi anemia from August 2014 to May 2020 at Armed Forces Institute of Pathology, Rawalpindi, Pakistan.

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(1) Background: Excessive intravenous therapy (EIV) is associated with negative consequences, but guidelines are unclear about when switching to oral therapy is appropriate. (2) Methods: This cohort included patients aged ≥18 years receiving ≥48 h of antimicrobial therapy for bacteremia due to , , Enterobacter, Klebsiella, Acinetobacter, or from 1/01/2008-8/31/2011. Patients with a polymicrobial infection or recurrent bacteremia were excluded.

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Article Synopsis
  • Glioblastoma is a highly aggressive brain tumor that remains difficult to treat, which has led researchers to explore unique metabolic pathways in these cancer cells.
  • In a study, three patients with suspected glioblastoma underwent advanced MRI scans using hyperpolarized pyruvate to analyze alterations in pyruvate metabolism before their tumors were surgically removed.
  • The results showed significantly increased lactate production in the tumors, indicating metabolic changes associated with glioblastoma, thereby providing potential insights into its progression and treatment.
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Purpose: The purpose of this study was to evaluate the impact of sugammadex on operating room (OR) times versus neostigmine in patients recovering from rocuronium or vecuronium induced neuromuscular blockade.

Methods: This retrospective cohort study evaluated patients 18 years or older with an American Society of Anesthesiologists (ASA) physical status of I-III who received sugammadex or neostigmine (January- October 2017) for reversal of rocuronium or vecuronium at a 500 bed, community hospital. Patients who were pregnant or breastfeeding were excluded.

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  • The study aimed to explore how regional differences affect the image quality of hyperpolarized carbon-13 (C) cardiac imaging and to find ways to improve this.
  • Researchers tested field map correction techniques in healthy participants by comparing different spiral readout durations and assessing their impact on image quality and performance.
  • Results showed that while shorter readouts maintained consistent image clarity, longer readouts improved signal-to-noise ratio but introduced more artifacts; however, these could be partially corrected using the new MFI method.
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  • Traumatic brain injury (TBI) leads to complex secondary injury processes, impacting brain metabolism and function immediately after the initial injury.* -
  • Magnetic resonance spectroscopic imaging (MRSI) with hyperpolarized C-labeled substrates allows for real-time, non-invasive mapping of metabolic changes in the brain following TBI.* -
  • In a study of two patients with mild TBI, imaging revealed reduced bicarbonate production and hyperintense lactate in one patient, highlighting the potential of this technology to detect metabolic alterations after brain injury.*
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Piperacillin/tazobactam (TZP) has been associated with nephrotoxicity in patients receiving vancomycin. Its impact on nephrotoxicity in patients with Gram-negative bacteraemia (GNB) is unclear. This study evaluated the impact of TZP on nephrotoxicity in patients with GNB.

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The fracture of an inferior vena cava filter strut and its migration to the heart is a rare sequela of implanted inferior vena cava filters. Perforation through the right ventricle into the pericardium with resultant cardiopulmonary compromise is even less frequent. We report the case of a 53-year-old man who presented with chest pain and hypotension consequent to cardiac tamponade.

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Objectives: This study sought to assess the utility of ultrasound (US) guidance for transradial arterial access.

Background: US guidance has been demonstrated to facilitate vascular access, but has not been tested in a multicenter randomized fashion for transradial cardiac catheterization.

Methods: We conducted a prospective multicenter randomized controlled trial of 698 patients undergoing transradial cardiac catheterization.

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Cell transplantation is an innovative technology that involves the implantation of a variety of myogenic and angiogenic cell types. The transplanted cells proliferate and augment left ventricular performance and therein ameliorate the heart failure symptoms. The concept of cell transplantation has followed the footsteps of angiogenesis starting as bench side research.

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Cardiovascular disease (CVD) in the developed countries continues to grow at an epidemic proportion. There are a significant number of young adults with no clinical evidence of CVD, but who have two or more risk factors that predispose them to CV events and death. Many of these risk factors are modifiable, and by controlling these factors, the CVD burden can be decreased significantly.

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The prevalence of ischemic heart disease (IHD) has been increasing among the women in developed countries. The well recognized IHD excess in men has often obscured the fact that IHD is the leading cause of death in women. Women have atypical symptoms of IHD that lead to a delay in the diagnosis and an overall poor prognosis.

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We report a case of successful treatment of a severely diseased saphenous vein graft from the transradial approach. Initial rheolytic thrombectomy was performed followed by coronary stenting through a 6 French guide catheter. Continuing miniaturization of interventional devices increases the utility of the transradial approach.

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The present study prospectively evaluated adjunctive antiplatelet therapy in patients without insulin-requiring diabetes during elective coronary stenting. Three hundred patients were randomized to one of three treatment groups: clopidogrel pretreatment, adjunctive abciximab, or control. Stenting was successful in 98% and no deaths occurred.

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