Publications by authors named "Jafarzadeh A"

Background And Aims: This study aimed to evaluate the effectiveness, safety, and satisfaction rates of three different lateral matricectomy methods for treating ingrown toenails: 90% phenol, 100% trichloroacetic acid (TCA), and radiofrequency (RF) ablation. Our objective was to identify which method offers superior outcomes regarding postoperative pain, healing time, aesthetic results, and complication rates.

Methods: Conducted between August 2022 and June 2023, the study included 12 eligible patients divided into three groups: Group 1 underwent lateral matricectomy with 90% phenol, Group 2 with 100% TCA, and Group 3 with RF treatment.

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Burn scars present psychological and social challenges for patients, classified into atrophic and hypertrophic types. Treatments like corticosteroid injections, laser therapy, and platelet-rich plasma (PRP) injections are commonly recommended for hypertrophic scars, while regenerative medicine and fractional CO2 lasers are linked to some degree of improvement for atrophic scars. Hypopigmented and depigmented burn scars pose ongoing challenges for healthcare providers and patients, with therapies such as intense pulsed light and fractional CO2 laser showing variable effects in treating these conditions.

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During the early days of the COVID-19 pandemic, low dose radiation therapy (LDRT) was proposed as a potentially effective treatment method. To minimize potential toxicity, the initial treatment approach involved a few mGy of adapting radiation followed by a single 250 mGy whole lung challenging dose. However, antiviral drugs were also introduced as a promising treatment option, which were thought to have the potential to revolutionize the management of the crisis.

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Leptin, an immune-regulating protein, enhances the maturation of dendritic cells (DCs). We previously demonstrated that leptin and lipopolysaccharide (LPS) promote the expression of co-stimulatory molecules on the surface of DCs. Leptin/LPS-treated DCs increased T cell responses against 4T1 breast cancer in mice.

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Obsessive-compulsive disorder (OCD) is the fourth most common psychiatric disorder with a significant morbidity rate. Despite various treatment modalities and medications, some patients show no definitive response. The aim of this study is to classify the medications of OCD with machine learning (ML) methods and to compare the classification performances of the decision tree (DT), chi-square automatic interaction detection (CHAID) algorithm, and linear model in ML methods.

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Aims And Objectives: The aim of this study is to examine the efficacy and safety of various regenerative medicine treatments, such as cell therapy, platelet-rich plasma (PRP), plasma-poor platelet (PPP), plasma-rich fibrin (PRF), mesenchymal stem cells, stromal vascular fraction (SVF), exosomes, adipose-derived stem cells (ADSC), and stem cell-conditioned media (SC-CM), for treating vitiligo.

Method: We conducted a thorough search of major databases such as PubMed, Scopus, and Web of Science, and selected 48 articles based on specific criteria. We used EndNote X8 and Google Sheets to review and extract data from the articles.

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Background And Aims: In recent years, the application of various light and laser devices in the treatment of different types of alopecia has been established. This systematic review aims to assess the efficacy and safety of laser therapy and phototherapy in cicatricial and non-cicatricial alopecia.

Methods: A comprehensive search was conducted on PubMed, Scopus, Science Direct, and Google Scholar.

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Fast urbanization can result in significant stormwater runoff pollution due to changes in land use. A 3-year study on the distribution and temporal variations of urban water pollutants in stormwater runoff was conducted, with a specific focus on the influence of land-use patterns in the recharge zone of a regional karst aquifer in Texas (Edwards Aquifer). The presence and concentration of various water pollutants including total suspended solids (TSS), total dissolved solids (TDS), nutrients (nitrite, nitrate, ammonia and phosphate), total carbon (TC) and total organic carbon (TOC), oil and grease (O&G), and eight heavy metals (Fe, Mg, Cu, Pb, Zn, Ni, Cr, Cd) were measured in stormwater samples collected from three bioswales.

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Background: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare, severe, and potentially life-threatening skin and mucous membrane disorders. They are characterized by widespread skin and mucosal detachment and necrosis, and are classified based on the percentage of total body surface area (TBSA) affected. Given the severe and often life-threatening nature of these conditions, the identification and implementation of effective treatments is crucial.

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The increasing urbanization and land development poses significant water quality challenges in urban areas. Stormwater control measures, such as bioretention basins, are implemented to mitigate these issues by managing storm volumes and improving water quality. Despite their widespread use, the effectiveness of bioretention basins in removing pollutants, particularly heavy metals and polycyclic aromatic hydrocarbons (PAHs), remains unclear.

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Article Synopsis
  • Nonmelanoma skin cancer, particularly basal cell carcinoma (BCC), is the most common type of skin malignancy worldwide, highlighting the need for effective early detection strategies.
  • This study analyzed clinical and pathological records of 229 BCC patients, revealing a high diagnostic accuracy, with 80.3% of cases confirmed as BCC upon pathological review and a significant number (42%) lacking prior clinical diagnoses.
  • The findings stress the importance of better training for healthcare providers in recognizing BCC symptoms and suggest increased collaboration with dermatologists to enhance diagnostic skills and patient outcomes.
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Background: Acne is a chronic inflammatory skin disease that negatively affects patients' quality of life. Increasing antibiotic resistance is making acne less responsive to treatment. Probiotics are live microorganisms that can provide health benefits by fighting pathogens and maintaining intestinal homeostasis and skin microbiome balance.

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Managing burn scars in children presents significant challenges. This study investigates effective treatment methods for burn scars, focusing on efficacy, safety, standard protocols and tolerability. Major databases such as PubMed, Scopus and Web of Science were thoroughly searched up to August 2024, emphasizing procedural treatments for burn scars in children.

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  • Skin scarring from burns, injuries, stretch marks, and acne can lead to both cosmetic and functional challenges, prompting various treatment options like lasers and platelet-rich plasma (PRP).
  • A study from 2022 to 2023 evaluated the effectiveness of PRP, hyaluronic acid, and their combination on burn scars in 10 patients, using techniques such as laser treatment and multiple assessments.
  • Results showed significant improvements in scar quality and patient satisfaction with PRP and hyaluronic acid treatments, while the placebo group showed no significant change; the combination therapy was particularly effective.
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Apelin, a bioactive peptide that serves as an endogenous ligand for the apelin receptor (APJ), is overexpressed in various types of cancers and contributes to cancer cell proliferation, viability, migration, angiogenesis, and metastasis, as well as immune deviation. Noncoding RNAs (ncRNAs) regulate gene expression, and there is growing evidence suggesting a bidirectional crosstalk between ncRNAs (including long noncoding RNAs [lncRNAs], circular RNAs [circRNAs], and microRNAs [miRNAs]) and apelin in cancers. Certain miRNAs can directly target the apelin and inhibit its expression, thereby suppressing tumor growth.

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  • Pulsed dye laser (PDL) treatment has shown effectiveness in resolving lupus miliaris disseminatus faciei (LMDF) in cases where drug therapies have been unsuccessful.
  • A 28-year-old male with persistent facial eruptions confirmed as LMDF received PDL after failed treatments with isotretinoin and methotrexate, leading to significant improvement without scarring.
  • Early intervention with PDL may enhance treatment outcomes and reduce the risk of disease relapse, indicating the need for further research on laser therapy's role in managing LMDF.
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  • * The SOCS family of proteins regulates this pathway's activity; irregular expression of these proteins in prostate cancer cells can trigger multiple signaling pathways that support tumor progression and therapy resistance.
  • * Understanding how SOCS proteins are dysregulated in prostate cancer could help develop new treatments aimed at restoring their expression, potentially improving therapy outcomes and managing the disease effectively.
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Background: Acne vulgaris is a common inflammatory skin disease that occurs during puberty, affecting approximately 85% of young adults and may persist into adulthood. The pathophysiology of acne is multifactorial, involving hormonal, inflammatory, and immune mechanisms. Isotretinoin is widely used for treating severe cystic acne or recurrent acne.

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Bioretention basins are extensively used in urban areas to manage stormwater by reducing peak flows and pollution. This study evaluated the performance of a bioretention basin in removing heavy metals, polycyclic aromatic hydrocarbons (PAHs), and oil and grease. Using droplet digital PCR (ddPCR), the presence of metal resistance genes (MRGs) and antibiotic resistance genes (ARGs) in the basin's soil was analyzed.

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Aims: Acute lymphoblastic leukemia (ALL) is the most common type of pediatrics cancer. Chemokines exert different roles in leukemia process through leukocyte recruitment and regulation of disease severity. Due to the prominent roles of chemokine/receptor axes, this study aimed to measure the blood expression levels of CCR4 and their ligands in pediatrics with B-cell ALL (B-ALL).

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Advances in human stem cell technologies enable induced pluripotent stem cells (iPSCs) to be explored as potent candidates for treating various diseases, such as malignancies, autoimmunity, immunodeficiencies, and allergic reactions. iPSCs with infinite self-renewal ability can be derived from different types of somatic cells without the ethical issues associated with embryonic stem cells. To date, numerous cell types, including various immune cell subsets [CD4 and CD8 T cells, gamma delta T (γδ T) cells, regulatory T cells, dendritic cells, natural killer cells, macrophages, and neutrophils] have successfully been generated from iPSCs paving the way for effective adoptive cell transfer therapy, drug development, and disease modeling.

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Helicobacter pylori (H. pylori) colonizes the stomach and leads to the secretion of a vast range of cytokines by infiltrated leukocytes directing immune/inflammatory response against the bacterium. To regulate immune/inflammatory responses, suppressors of cytokine signaling (SOCS) proteins bind to multiple signaling components located downstream of cytokine receptors, such as Janus kinase (JAK), signal transducers and activators of transcription (STAT).

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Background: Bariatric surgery, a significant intervention for obesity, may influence weight loss through changes in gut microbiota, particularly the Firmicutes and Bacteroidetes. This study explores these potential shifts and their metabolic implications.

Materials: We conducted a cross-sectional study involving patients who had undergone bariatric surgery.

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Article Synopsis
  • This study systematically reviews randomized controlled trials on regenerative medicine techniques (like platelet-rich plasma and cell therapy) for treating specific skin diseases but excludes skin rejuvenation and scarring.
  • The researchers searched major databases up to January 2024, analyzing 64 studies with 2888 participants, focusing on diseases such as androgenetic alopecia and vitiligo.
  • Results showed significant improvements, with up to 68.4% enhancement in androgenetic alopecia and 71% in vitiligo, indicating regenerative medicine is an effective treatment option for various dermatologic conditions.
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  • Phototherapy, particularly UVB treatment, is effective for various skin diseases, including psoriasis, but can lead to vesiculobullous lesions that may indicate Bullous Systemic Lupus Erythematosus (BSLE).
  • BSLE is a rare form of lupus that presents as blisters and can be diagnosed through specific immunofluorescence findings.
  • The study discusses a case of a 70-year-old man with vesicular lesions after UVB therapy, confirming BSLE and noting improvement with dapsone treatment, emphasizing the need to consider BSLE in similar cases.
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