Comparative Safety Profiles of Sedatives Commonly Used in Clinical Practice: A 10-Year Nationwide Pharmacovigilance Study in Korea.

This study aims to compare the prevalence and seriousness of adverse events (AEs) among sedatives used in critically ill patients or patients undergoing invasive procedures and to identify factors associated with serious AEs. Retrospective cross-sectional analysis of sedative-related AEs voluntarily reported to the Korea Adverse Event Reporting System from 2008 to 2017 was performed. All AEs were grouped using preferred terms and System Organ Classes per the World Health Organization-Adverse Reaction Terminology.

A Nationwide Survey on the Facilities and Personnel for Endoscopic Sedation: Results from 50 Qualified Endoscopy Units of Teaching Hospitals Accredited by the Korean Society of Gastrointestinal Endoscopy (KSGE).

Background/aims: This study aimed to determine the current status of facilities, equipment, and personnel for endoscopic sedation from endoscopy units of representative hospitals in South Korea.

Methods: A questionnaire survey was conducted on 50 qualified endoscopy units accredited by the Korean Society of Gastrointestinal Endoscopy.

Results: All included endoscopy units had regulations and educational programs regarding sedation training for endoscopists and nursing personnel.

Simple transscleral fixation of IOL technique without tying up haptics.

Aim: To introduce a novel technique for transscleral fixation of the posterior chamber intraocular lens (PC-IOL) that requires no sutures on the IOL haptics.

Methods: Instead of suturing polypropylene onto the IOL haptics, the method simply winds the thread on the haptics. Fifteen eyes of 15 patients underwent this technique and were followed up for more than 18mo.

Preparation and Characterization of Nanostructured Manganese Oxide for Supercapacitors.

Nanostructured manganese oxides were synthesized by a sol-gel method using manganese acetate (MnAc2) and citric acid (C6H8O7,) as precursors, and characterized by Brunauer-Emmett-Teller (BET) analysis, Barrett-Joyner-Halenda (BJH), X-ray diffraction (XRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM) techniques. The nano-rod structure of MnO2 developed gradually when the calcination temperature varied from 380 to 580 degrees C. As the pH increased, the pore size increased, while the specific surface area decreased.

Design and synthesis of 4-O-methylhonokiol analogs as inhibitors of cyclooxygenase-2 (COX-2) and PGF₁ production.

A series of novel 4-O-methylhonokiol analogs were synthesized in light of revealing structure-activity relationship for inhibitory effect of COX-2 enzyme. The key strategy of the molecular design was oriented towards modification of the potential metabolic soft spots (e.g.

Ultrasonographic features of pyonephrosis in dogs.

Pyonephrosis refers an infected hydronephrotic kidney which arise from pyelonephritis followed by exudate accumulation in a dilated renal pelvis or hydronephrosis followed by ascending infection. Pyonephrosis may cause serious systemic complications, making prompt and reliable diagnosis critical. Clinical and ultrasonographic findings are used for the diagnosis of pyonephrosis in humans, but these findings have not been investigated in dogs.

Structure-activity relationship of indoline-2-carboxylic acid N-(substituted)phenylamide derivatives.

Chroman derivatives exhibited potent inhibitory activity of NF-kappaB. For SAR, the chroman scaffold was modified with an indoline moiety. A series of indoline-2-carboxylic acid N-(substituted)phenylamide derivatives were synthesized to explore their inhibitory activities of NF-kappaB and they were also evaluated for cytotoxicity against various cancer cell lines.