Publications by authors named "Jaeson Michael Grasmick"
Stem Cell Reports
March 2014
Article Synopsis
- Human pluripotent stem cells (hPSCs) can be differentiated to generate specific neurons, particularly from the hippocampal dentate gyrus (DG), useful for studying brain diseases.
- The differentiation protocol mirrors key gene expression patterns and neuron maturation, producing neurons that can integrate functionally into the DG.
- When applied to stem cells from schizophrenia patients, the protocol revealed deficits in generating DG neurons, suggesting neurodevelopmental issues in schizophrenia and potential applications for drug screening and personalized treatments.
