Publications by authors named "Jaeson M Grasmick"
Comparative analyses of neuronal phenotypes in closely related species can shed light on neuronal changes occurring during evolution. The study of post-mortem brains of nonhuman primates (NHPs) has been limited and often does not recapitulate important species-specific developmental hallmarks. We utilize induced pluripotent stem cell (iPSC) technology to investigate the development of cortical pyramidal neurons following migration and maturation of cells grafted in the developing mouse cortex.
View Article and Find Full Text PDFArticle Synopsis
- Human pluripotent stem cells (hPSCs) can be differentiated to generate specific neurons, particularly from the hippocampal dentate gyrus (DG), useful for studying brain diseases.
- The differentiation protocol mirrors key gene expression patterns and neuron maturation, producing neurons that can integrate functionally into the DG.
- When applied to stem cells from schizophrenia patients, the protocol revealed deficits in generating DG neurons, suggesting neurodevelopmental issues in schizophrenia and potential applications for drug screening and personalized treatments.