Investigation of sex-related functional connectivity alterations in autism using class imbalance mitigation approach.

Autism spectrum disorder is primarily diagnosed in males, leading to the lack of understanding of brain disorganization in female individuals with autism. To fill the gap, we applied a Gaussian mixture model-based oversampling technique to the functional connectivity data to adjust for the sex imbalance in autism. Leveraging a dimensionality reduction technique, we generated a low-dimensional principal component (i.

Sex differences in autism spectrum disorder using class imbalance adjusted functional connectivity.

Autism spectrum disorder (ASD) is an atypical neurodevelopmental condition with a diagnostic ratio largely differing between male and female participants. Due to the sex imbalance in participants with ASD, we lack an understanding of the differences in connectome organization of the brain between male and female participants with ASD. In this study, we matched the sex ratio using a Gaussian mixture model-based oversampling technique and investigated the differences in functional connectivity between male and female participants with ASD using low-dimensional principal gradients.