Publications by authors named "Jaeho Yang"

In this work, we propose a new method for ordering nets during the process of layer assignment in global routing problems. The global routing problems that we focus on in this work are based on routing problems that occur in the design of substrates in multilayered semiconductor packages. The proposed new method is based on machine learning techniques and we show that the proposed method supersedes conventional net ordering techniques based on heuristic score functions.

View Article and Find Full Text PDF

Deep learning (DL)-based image analysis has recently seen widespread application in digital pathology. Recent studies utilizing DL in cytopathology have shown promising results, however, the development of DL models for respiratory specimens is limited. In this study, we designed a DL model to improve lung cancer diagnosis accuracy using cytological images from the respiratory tract.

View Article and Find Full Text PDF
Article Synopsis
  • A retro-odontoid mass (R-OM) is a non-cancerous growth located behind the dens bone in the upper cervical spine, which can affect patients' health.
  • A study involving 69 patients who underwent various types of upper cervical spine surgeries revealed that post-surgery, there was significant improvement in both radiographic measurements and clinical symptoms.
  • Results indicated that most R-OMs decreased in size or resolved after fusion surgery, emphasizing the importance of stabilization procedures to effectively treat this condition.
View Article and Find Full Text PDF

Purpose: To investigate the radiologic and clinical outcomes of direct internal fixation for unstable atlas fractures.

Materials And Methods: This retrospective study included 12 patients with unstable atlas fractures surgically treated using C1 lateral mass screws, rods, and transverse connector constructs. Nine lateral mass fractures with transverse atlantal ligament (TAL) avulsion injury and three 4-part fractures with TAL injury (two avulsion injuries, one TAL substance tear) were treated.

View Article and Find Full Text PDF

HAD-B1 is a Korean herbal formula designed to treat solid tumors, and through cell experiments, it has proven to have an anticancer effect. The current study aims to test the safety of HAD-B1. This experiment is under the regulation of ICH.

View Article and Find Full Text PDF

Perfluoroalkyl compounds (PFCs) as food contaminants are widely distributed persistent organic pollutants (POPs) and have been suggested to induce immune dysfunction. However, their effects on immune function are not conclusive. Mast cells play a central role in allergic and non-allergic inflammatory responses.

View Article and Find Full Text PDF

This study investigated the efficacy of a novel surgical method that relies on the transient fixation of L4 in Lenke Type 5C and 6C adolescent idiopathic scoliosis. Thirty-six transient surgically treated L4 fixation patients were retrospectively evaluated. The first surgery involved mechanical correction of scoliosis; the lowest instrumented vertebra (LIV) was L4.

View Article and Find Full Text PDF

Acrylamide is known as a neurotoxicant found in commonly consumed food as well as in human body. However, the underlying mechanisms involved in neurotoxicity by acrylamide and its metabolite, glycidamide remain largely unknown. In this study, we have examined the interplay between CYP2E1, AMPK, ERK and PKC in acrylamide-induced neurotoxicity associated with autophagy in PC12 cells.

View Article and Find Full Text PDF

Patients with lumbar spinal stenosis may exhibit symptoms such as back pain, radiating pain, and neurogenic claudication. Although long-term outcome of treatments manifests similar results for both nonsurgical and surgical treatments, positive effects such as short-term improvement in symptoms and decreased fall risk may be expected with surgery. Surgical treatment is basically decompression, and a combination of treatments can be added depending on the degree of decompression and the accompanying instability.

View Article and Find Full Text PDF
Article Synopsis
  • This study examines the prevalence of gastrointestinal (GI) and cardiovascular (CV) risk factors in patients with degenerative lumbar spinal disease (DLSD) who are planning surgery.
  • The findings reveal that over 59% of these patients have high GI risk and 66% have metabolic syndrome, indicating significant CV risk; about 40% have both risk factors simultaneously.
  • Additionally, the study highlights a misalignment between actual NSAID prescriptions and current treatment guidelines, suggesting a need for better risk assessment before prescribing.
View Article and Find Full Text PDF

There are a few studies on the postoperative changes in sagittal alignment and corresponding factors, including hand grip strength (HGS) and muscle performance tests for lumbar spinal stenosis (LSS). Thus, we aimed to determine whether HGS can be a surrogate marker for global sagittal alignment changes after decompression with fusion surgery for LSS. This retrospective observational study included 91 patients who underwent spine fusion surgery for LSS.

View Article and Find Full Text PDF
Article Synopsis
  • Deep learning models can find new drug candidates, but they often create invalid molecules that can't be used in research.
  • The proposed conditional variational autoencoder (CVAE) model generates valid drug candidates by using molecular fingerprints and growth inhibition data specifically for breast cancer.
  • Our CVAE not only generates useful molecular fingerprints for drug discovery but can also enhance database searches by serving as expanded queries for retrieving relevant information.
View Article and Find Full Text PDF

Background Context: There has been limited research on the association between hand grip strength (HGS) as one of the diagnostic criteria for sarcopenia and surgical outcomes of lumbar spinal stenosis (LSS).

Purpose: We aimed to determine the effect of HGS on surgical outcomes and risk of fall in patients with LSS.

Study Design: This is a retrospective observational study.

View Article and Find Full Text PDF
Article Synopsis
  • A retrospective study was conducted to compare the outcomes of spinal surgery versus nonsurgical treatment for scoliosis in 199 boys with Duchenne muscular dystrophy (DMD) over an average period of 6.4 years.
  • The study aimed to evaluate the impact of surgical intervention on functional status, respiratory function, and survival rates through various measures, including radiologic parameters and the Swinyard scale.
  • Results indicated that while baseline conditions were similar, the surgical group showed significant improvements in spinal alignment and functional status over time compared to the nonsurgical group.
View Article and Find Full Text PDF

Anterior cruciate ligament reconstruction (ACLR) frequently results in quadriceps atrophy. The present study investigated the effect of ACLR on the muscle thickness of the different constituent muscles of the quadriceps and circulating biomarkers related to muscle atrophy and hypertrophy. Fourteen subjects underwent anterior cruciate ligament reconstruction following injury.

View Article and Find Full Text PDF
Article Synopsis
  • This study examined the effects of fusion level (C7 vs. T1) on cervical spine alignment in patients who underwent multilevel posterior cervical fusion surgery.
  • Results showed that patients with C7 fusion experienced worsening sagittal alignment and increased T1 slope, while those with T1 fusion maintained their alignment post-surgery.
  • The study concludes that extending the distal fusion level to T1 is recommended to better maintain sagittal balance after cervical spine surgery.
View Article and Find Full Text PDF
Article Synopsis
  • * Using bovine bone blocks, researchers tested 4-mm by 10-mm implants at different torques and measured the correlation between these methods.
  • * Results showed a strong inverse correlation between resonance frequency and implant damping (r = -0.98), while the correlation with insertion torque was weak, helping clinicians in determining when to load dental implants.
View Article and Find Full Text PDF

Background: N-containing bisphosphonates (BPs), such as pamidronate and risedronate, can inhibit osteoclastic function and reduce osteoclast number by inducing apoptotic cell death in osteoclasts. The aim of this study is to demonstrate the effect of pamidronate, second generation nitrogen-containing BPs and to elucidate matrix metallo-proteinases (MMPs) mRNA expression under serum starvation and/or tumor necrosis factor alpha (TNF-α) stimulation on metabolism of intervertebral disc (IVD) cells in vitro.

Methods: Firstly, to test the effect of pamidronate on IVD cells in vitro, various concentrations (10(-12), 10(-10), 10(-8), and 10(-6) M) of pamidronate were administered to IVD cells.

View Article and Find Full Text PDF

Objectives: It has been reported that good spinal sagittal alignment reduces the risk of fall and positive sagittal balance is the radiographic parameter that is most highly correlated with adverse health outcomes. However, no reports have demonstrated a change in risk of falling in patients with lumbar spinal stenosis (LSS) according to sagittal balance status.

Patients And Methods: From September 2013 to October 2014, 141 patients who underwent lumbar spine surgery, including decompression and fusion in-situ for LSS, were enrolled in this study.

View Article and Find Full Text PDF

Early life neuronal exposure to environmental toxicants has been suggested to be an important etiology of neurodegenerative disease development. Perfluorohexanesulfonate (PFHxS), one of the major perfluoroalkyl compounds, is widely distributed environmental contaminants. We have reported that PFHxS induces neuronal apoptosis via ERK-mediated pathway.

View Article and Find Full Text PDF

Perfluorohexanesulfonate (PFHxS), one of the major perfluoroalkyl compounds (PFCs), has been used in a variety of industrial and consumer applications and detected in serum in the general population. This raised a concern over its possible detrimental health effects, including neurotoxic effects. We have previously shown that PFHxS induced neuronal apoptosis via the NMDA receptor-mediated extracellular signal-regulated kinase (ERK) pathway.

View Article and Find Full Text PDF

Background: Bone mineral density (BMD) is known to have a positive correlation with lean body mass. Several studies have also reported the positive correlation between muscle power and BMD. From this point of view, we hypothesized BMD of lumbar spine to have a positive correlation with muscle mass.

View Article and Find Full Text PDF

Purpose: The purpose of this study was to investigate the marginal fit of metal-free crowns made by three different computer-aided design/computer-aided manufacturing (CAD/CAM) systems.

Materials And Methods: The maxillary left first premolar of a dentiform was prepared for all-ceramic crown restoration. Thirty all-ceramic premolar crowns were made, ten each manufactured by the Lava system, Cercon, and Cerec.

View Article and Find Full Text PDF

This study investigated the effect of digital veneering system (DVS) on strengthening the bond between a zirconia core and ceramic veneer. Specimens for Groups 1 (negative control), 2 (positive control), 3, and 4 used conventional porcelain veneering technique on untreated, sandblasted, coloring agent-treated, and modifier-treated zirconia cores respectively. Group 5 used DVS, where glass ceramic veneers—produced by computer-aided milling—were fused to zirconia cores.

View Article and Find Full Text PDF

This study evaluated the effects of drill wear on bone temperature during osteotomy preparation with 3 types of drills and compared heat production between drills. The drills used in this study were titanium nitride-coated metal, tungsten carbide carbon-coated metal, and zirconia ceramic drills. An osteotomy 11 mm in depth was formed in bovine scapular bone following the manufacturer's recommended drill sequences.

View Article and Find Full Text PDF