Exploring epigenetic strategies for the treatment of osteoporosis.

The worldwide trend toward an aging population has resulted in a higher incidence of chronic conditions, such as osteoporosis. Osteoporosis, a prevalent skeletal disorder characterized by decreased bone mass and increased fracture risk, encompasses primary and secondary forms, each with distinct etiologies. Mechanistically, osteoporosis involves an imbalance between bone resorption by osteoclasts and bone formation by osteoblasts.

Strain improvement of for increased l-leucine aminopeptidase and protease production.

Conventional random mutagenesis was implemented to improve l-leucine aminopeptidase (LAP) and protease production in . Through successive mutagenesis by ethyl methanesulfonate (EMS), UV, and 1-methyl-2-nitro-1-nitrosoguanidine (NTG), EMS25, EU36, and EUN13 mutants from each mutagenesis process were screened using a newly developed quick and easy screening method. The mutant EUN13 exhibited a 9.

Psychometric Properties of the Alcohol Use Disorders Identification Test-Consumption (AUDIT-C) in Public First Responders.

Problematic alcohol consumption is prevalent among first responders because alcohol is commonly used to cope with occupational stress and frequent exposure to traumatic incidents, making them an at-risk population for alcohol use disorders (AUD). This study investigated the psychometric properties of the Korean version of the Alcohol Use Disorders Identification Test-Consumption (AUDIT-C) among public first responders. The Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders-IV-Text Revision (SCID), AUDIT-C, AUDIT, and CAGE were administered to 222 public first responders, who were recruited by convenience sampling.

Characterization of Isolated from Meju, Korean Traditional Fermented Soybean Brick.

Initially, we screened 18 -like strains from spp. isolated from meju (Korean traditional fermented soybean brick) according to their morphological characteristics. Because members of section are often incorrectly identified because of their phylogenetic similarity, we re-identified these strains at the morphological and molecular genetic levels.

Central Nervous System and its Disease Models on a Chip.

Technologies for microfluidics and biological microelectromechanical systems have been rapidly progressing over the past decade, enabling the development of unique microplatforms for in vitro human central nervous system (CNS) and related disease models. Most fundamental techniques include manipulation of axons, synapses, and neuronal networks, and different culture conditions are possible, such as compartmental, co-culturing, and 3D. Various CNS disease models, such as Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis (MS), epilepsy, N-methyl-D-aspartate receptor (NMDAR) encephalitis, migraine, diffuse axonal injury, and neuronal migration disorders, have been successfully established on microplatforms.

Concise Review: Stem Cell Microenvironment on a Chip: Current Technologies for Tissue Engineering and Stem Cell Biology.

Unlabelled: Stem cells have huge potential in many therapeutic areas. With conventional cell culture methods, however, it is difficult to achieve in vivo-like microenvironments in which a number of well-controlled stimuli are provided for growing highly sensitive stem cells. In contrast, microtechnology-based platforms offer advantages of high precision, controllability, scalability, and reproducibility, enabling imitation of the complex physiological context of in vivo.

Validation of the Athens Insomnia Scale for screening insomnia in South Korean firefighters and rescue workers.

Purpose: Sleep problems are a major cause of occupational stress in firefighters and rescue workers. We evaluated the psychometric properties of the Athens Insomnia Scale (AIS) among South Korean firefighters and rescue workers.

Methods: Structured clinical interviews and self-report questionnaires were administered to 221 firefighters and rescue workers.

Validation of the Korean version of the Connor-Davidson Resilience Scale-2 in firefighters and rescue workers.

Objective: Resilience has been considered as a protective factor against stress. Evaluating resilience in firefighters and rescue workers, who are frequently exposed to traumatic events, is important and relevant. This study examined the psychometric properties of the Korean version of the Connor-Davidson Resilience Scale-2 (CD-RISC2).

Magnetic particle imaging with a planar frequency mixing magnetic detection scanner.

We present the first experimental results of our planar-Frequency Mixing Magnetic Detection (p-FMMD) technique to obtain Magnetic Particles Imaging (MPI). The p-FMMD scanner consists of two magnetic measurement heads with intermediate space for the analysis of the sample. The magnetic signal originates from the nonlinear magnetization characteristics of superparamagnetic particles as in case of the usual MPI scanner.