Publications by authors named "Jaeho Kim"

Article Synopsis
  • * A study involving 79 patients revealed high percentages of pain in MSA (73.9%), PSP (50.0%), DIP (67.9%), and VP (66.7%), but found no significant differences in sensory discrimination thresholds (SDT) between those with and without pain.
  • * The research concluded that the scaling function did not play a significant role in the development of pain among the different parkinsonian disorders studied.
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Neurodegenerative diseases (NDDs) present significant challenges due to limited treatment options, ethical concerns surrounding traditional animal models, and the time-consuming and costly process of using human-induced pluripotent stem cells (iPSCs). We addressed these issues by developing a 3D culture protocol for differentiating SH-SY5Y cells into glutamatergic neurons, enhancing physiological relevance with a 3D microarray culture plate. Our protocol optimized serum concentration and incorporated retinoic acid (RA) to improve differentiation.

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Article Synopsis
  • The study aimed to explore the differences in brain activity between patients with drug-induced parkinsonism (DIP) and those with Parkinson’s disease (PD) using resting-state electroencephalography (rsEEG).
  • Researchers analyzed rsEEG data from 15 DIP patients, 41 PD patients, and 12 healthy controls, finding distinct EEG patterns: DIP patients had higher theta band power and greater delta band coherence compared to PD patients.
  • The findings indicate that rsEEG could serve as an effective method for distinguishing between DIP and PD, potentially aiding in more accurate diagnoses.
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Industrial implementation of highly thermally conductive polymeric composites has been hindered by several hurdles, such as the low intrinsic thermal conductivity (TC) of polymers, the use of expensive thermally conductive fillers, and difficulty in processing composites with high filler loading. In this study, we introduce a straightforward fabrication method for a high TC polymeric composite with a programmed internal structure of a highly interconnected thermal conduction highway (HITCH) by the simple addition of partially cured resin fragments into the conventional filler/resin combination. Critical variables, such as the concentration of the added resin fragments and the local concentration of hexagonal boron nitride (hBN) in the HITCH, as well as the packing density of the fragments, were systematically tuned to maximize the TC with the use of the least amount of the filler.

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Background: Cerebrospinal fluid (CSF) flow is crucial for brain homeostasis and its dysfunction is highly associated with neurodegenerative diseases. Restoring CSF circulation is proposed as a key strategy for the treatment of the diseases. Among the methods to improve CSF circulation, focused ultrasound (FUS) stimulation has emerged as a promising non-invasive brain stimulation technique, with effectiveness evidenced by ex vivo studies.

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The widespread presence of micro(nano)plastics (MNPs) in the environment threatens ecosystem integrity, and thus, it is necessary to determine and assess the occurrence, characteristics, and transport of MNPs between ecological components. However, most analytical approaches are cost- and time-inefficient in providing quantitative information with sufficient detail, and interpreting results can be difficult. Alternative analyses integrating novel measurements by imaging or proximal sensing with signal processing and machine learning may supplement these approaches.

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The Korean Dementia Association (KDA) has been organizing biennial international academic conferences since 2019, with the International Conference of the KDA (IC-KDA) 2023 held in Busan under the theme 'Beyond Boundaries: Advancing Global Dementia Solutions.' The conference comprised 6 scientific sessions, 3 plenary lectures, and 4 luncheon symposiums, drawing 804 participants from 35 countries. Notably, a Korea-Taiwan Joint Symposium addressed insights into Alzheimer's disease (AD).

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Objective: We aimed to examine the potential association between migraine and vascular dementia (VaD) using a nationwide population database.

Background: Migraine and VaD showed similar structural and functional changes in pathophysiology process and shared common risk factors, However, whether migraine prevalence increases VaD incidence remains controversial.

Methods: This retrospective population-based cohort study used the medical records from the Korean National Health Insurance System database.

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Although robustness of connectivity and modular structures in networks have been attracted much attentions in complex networks, most researches have focused on those two features in Erdos-Renyi random graphs and Scale-Free networks whose degree distributions follow Poisson and power-law, respectively. This paper investigates the effect of modularity on robustness in a modular d-regular graphs. Our results reveal that high modularity reduces the robustness even from the optimal robustness of a random d-regular graph in the pure effect of degree distributions.

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Background: Acupuncture treatment for tinnitus has received attention owing to its potential as an alternative to conventional treatment modalities. We conducted a scoping review to identify detailed information on acupuncture treatment methods used in clinical studies and to provide useful information for practitioners, patients, and researchers.

Methods: MEDLINE, Cochrane Central Register of Controlled Trials (CENTRAL), Embase, Oriental Medicine Advanced Searching Integrated System (OASIS), Korean Research Information Sharing Service (RISS), DataBase Periodical Information Academic (DBPIA), and the China National Knowledge Infrastructure (CNKI) were searched from their inception to December 2023.

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Bone differentiation is crucial for skeletal development and maintenance. Its dysfunction can cause various pathological conditions such as rickets, osteoporosis, osteogenesis imperfecta, or Paget's disease. Although traditional two-dimensional cell culture systems have contributed significantly to our understanding of bone biology, they fail to replicate the intricate biotic environment of bone tissue.

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Article Synopsis
  • A human induced pluripotent stem cell (iPSC) line was created from blood cells of a 59-year-old male with Alzheimer's disease.
  • *The iPSC line was carefully analyzed to ensure it can differentiate into various cell types, has no foreign genes, and has a typical chromosome set.
  • *The identification of a specific genetic variant (M232R) in the PRNP gene adds significance to this cell line for studying the causes of Alzheimer's disease.*
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  • - Recently, researchers have developed monocular 3D human pose estimation (HPE) methods to accurately predict 3D poses, but challenges like depth ambiguity and occlusions persist.
  • - Previous diffusion model-based approaches attempted to overcome these difficulties by reconstructing poses from noisy initial data using 2D keypoints and spatial-temporal information, but they often lack peak performance or take too long to improve.
  • - The new HDPose model tackles these issues effectively by using a hierarchical structure to aggregate spatial and temporal information, resulting in faster convergence and improved accuracy on the Human3.6M and MPI-INF-3DHP datasets, making it lightweight and competitive with existing state-of-the-art models.
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Ir(triNHC) complexes catalyzed glycerol and alcohol dehydrogenative coupling, yielding diverse α-hydroxy acids. Unlike conventional conditions, Ir(triNHC) facilitated additional C-C bond formation after lactic acid production from glycerol, exhibiting high TOFs. This protocol successfully converted 1,2-propanediol and sorbitol into α-hydroxy acids, highlighting biomass-derived sources' potential as valuable platform chemicals.

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Background: To evaluate the degree of deformation in patients with ankle osteoarthritis (OA), it is essential to measure the three-dimensional (3D), in other words, stereoscopic alignment of the ankle, subtalar, and foot arches. Generally, measurement of radiological parameters use two-dimensional (2D) anteroposterior and lateral radiographs in a weight-bearing state; however, computer-aided 3D analysis (Disior) using weight-bearing cone-beam computed tomography (CBCT) has recently been introduced.

Methods: In this study, we compared the 2D human radiographic method with a stereoscopic image in patients with ankle arthritis.

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Perovskite solar cells (PSCs) have been significantly improved by utilizing an inorganic hole-transporting layer (HTL), such as nickel oxide. Despite the promising properties, there are still limitations due to defects. Recently, research on self-assembled monolayers (SAMs) is being actively conducted, which shows promise in reducing defects and enhancing device performance.

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LiDAR place recognition is a crucial component of autonomous navigation, essential for loop closure in simultaneous localization and mapping (SLAM) systems. Notably, while camera-based methods struggle in fluctuating environments, such as weather or light, LiDAR demonstrates robustness against such challenges. This study introduces the intensity and spatial cross-attention transformer, which is a novel approach that utilizes LiDAR to generate global descriptors by fusing spatial and intensity data for enhanced place recognition.

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Article Synopsis
  • A study investigated the link between migraine and the risk of developing Parkinson's disease (PD) using data from the Korean National Health Insurance System.* -
  • The research included over 214,000 patients with migraine and found that those with migraine had a 1.35 times higher risk of developing PD compared to those without migraine, despite a similar incidence between migraine patients with and without aura.* -
  • The study concluded that managing comorbid conditions and chronic migraine may help reduce PD incidence, and further clinical trials are needed to clarify this relationship.*
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The paradigm of the Internet of Things (IoT) and edge computing brings a number of heterogeneous devices to the network edge for monitoring and controlling the environment. For reacting to events dynamically and automatically in the environment, rule-enabled IoT edge platforms operate the deployed service scenarios at the network edge, based on filtering events to perform control actions. However, due to the heterogeneity of the IoT edge networks, deploying a consistent rule context for operating a consistent rule scenario on multiple heterogeneous IoT edge platforms is difficult because of the difference in protocols and data formats.

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Background: Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) gain attention as a potent cell source in regenerative medicine and drug discovery. With the necessity of the demands for experimental models to create a more physiologically relevant model of the heart in vitro we herein investigate a 3D culturing platform and a method for assessing rhythm in hiPSC-CMs.

Methods: The 3D cell culture PAMCELL™ plate is designed to enable cells to attach exclusively to adhesive patterned areas.

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Background And Objective: Migraine is a common chronic neurological disease characterized by pulsating headaches, photophobia, phonophobia, nausea, and vomiting. The prevalence of dementia in individuals aged over 65 years in Korea is more than 10%, and Alzheimer's disease (AD) dementia accounts for most cases. Although these two neurological diseases account for a large portion of the medical burden in Korea, few studies have examined the relationship between the two diseases.

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Background: The genetic basis of amyloid β (Aβ) deposition in subcortical vascular cognitive impairment (SVCI) is still unknown. Here, we investigated genetic variants involved in Aβ deposition in patients with SVCI.

Methods: We recruited a total of 110 patients with SVCI and 424 patients with Alzheimer's disease-related cognitive impairment (ADCI), who underwent Aβ positron emission tomography and genetic testing.

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NANOG, a stemness-associated transcription factor, is highly expressed in many cancers and plays a critical role in regulating tumorigenicity. Transformation/transcription domain-associated protein (TRRAP) has been reported to stimulate the tumorigenic potential of cancer cells and induce the gene transcription of NANOG. This study aimed to investigate the role of the TRRAP-NANOG signaling pathway in the tumorigenicity of cancer stem cells.

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CD4 T cells play major roles in the adaptive immune system, which requires antigen recognition, costimulation, and cytokines for its elaborate orchestration. Recent studies have provided new insight into the importance of the supramolecular activation cluster (SMAC), which comprises concentric circles and is involved in the amplification of CD4 T cell activation. However, the underlying mechanism of SMAC formation remains poorly understood.

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