Does H Temperature-Programmed Reduction Always Probe Solid-State Redox Chemistry? The Case of Pt/CeO.

Redox reactions on the surface of transition metal oxides are of broad interest in thermo, photo, and electrocatalysis. H temperature-programmed reduction (H-TPR) is commonly used to probe oxide reducibility by measuring the rate of H consumption during temperature ramps, assuming that this rate is controlled by oxide reduction. However, oxide reduction involves several elementary steps, such as H dissociation and H-spillover, before surface reduction and HO formation occur.

Beyond One-Size-Fits-All: Tailoring Teicoplanin Regimens for Normal Renal Function Patients Using Population Pharmacokinetics and Monte Carlo Simulation.

In patients with normal renal function, significant teicoplanin dose adjustments are often necessary. This study aimed to develop a population pharmacokinetic (PK) model for teicoplanin in healthy adults and use it to recommend optimal dosage regimens for patients with normal renal function. PK samples were obtained from 12 subjects and analyzed using a population approach.

Clinical and functional outcomes of TKA after HTO or UKA: a New Zealand Joint Registry Study.

Introduction: Surgical options for patients with unicompartmental knee osteoarthritis include high tibial osteotomy (HTO) or unicompartmental knee arthroplasty (UKA). When managing younger patients with a higher chance of further surgery, the outcome of any subsequent conversion to total knee arthroplasty (TKA) also needs to be considered. The aim of this study was to compare implant survivorship and patient-reported outcomes for patients undergoing TKA after previous HTO or UKA, with comparisons for age, gender and comorbidities.

Intrapulmonary and Systemic Pharmacokinetics of Colistin Following Nebulization of Low-Dose Colistimethate Sodium in Patients with Ventilator-Associated Pneumonia Caused by Carbapenem-Resistant .

Colistimethate sodium (CMS) nebulization is associated with reduced systemic toxicity compared to intravenous injection, with potentially enhanced clinical efficacy. This study aimed to assess the pharmacokinetic (PK) properties of colistin during low-dose CMS nebulization in patients with ventilator-associated pneumonia (VAP) caused by carbapenem-resistant . A nonlinear mixed-effects modeling approach was applied to develop population PK models for colistin in both epithelial lining fluid (ELF) and plasma.

Compliance After Re-Prescription for Positive Airway Pressure in Obstructive Sleep Apnea Patients Who Failed Positive Airway Pressure Therapy.

Background And Objectives: Little is known about studies evaluating positive airway pressure (PAP) compliance after re-prescription. Therefore, the aim of this study was to investigate PAP compliance after re-prescription in obstructive sleep apnea (OSA) patients who failed initial PAP therapy.

Methods: We retrospectively reviewed OSA patients who had received a re-prescription for PAP from March 2020 to June 2021.

Current status and trends of pulmonary rehabilitation in South Korea: National level data analysis using Health Insurance Review and Assessment Service (HIRA) database from 2016 to 2018.

In South Korea, there are few studies to understand the current status of pulmonary rehabilitation in clinical practice and develop it. This study aimed to assess the current status and annual changes in the number and pattern of prescriptions for pulmonary rehabilitation before and after its insurance coverage. The trends of pulmonary rehabilitation before and after its insurance coverage commencement were evaluated using the data of 24,380 patients during the 3-year period from 2016 to 2018 that were archived by the National Health Information Database of the Health Insurance Review and Assessment Service in South Korea.

A Rare Case of Well-Differentiated Parapharyngeal Liposarcoma.

Parapharyngeal liposarcoma is a rare malignant tumor, the pathogenesis of which is uncertain. Parapharyngeal liposarcoma often causes nonspecific clinical features, including dysphagia, globus sensation, and/or respiratory disturbances. The parapharyngeal space is a rare location for head and neck liposarcoma, and these lesions may therefore be confused with a variety of other tumors that can originate in this area.

Quantitative measure of concrete fragment using ANN to consider uncertainties under impact loading.

In this study, numerical analysis was performed to predict amount of fragments and travel distance after collision of a concrete median barrier with a truck under impact loading using Smooth Particle Hydrodynamics (SPH). The obtained results of the SPH analysis showed that amount of fragments and the travel distance can be changed depending on different velocity-to-mass ratios under same local impact energy. Using the results of the SPH analysis, artificial neural network (ANN) was constructed to consider the uncertainties for the prediction of amount of fragments and travel distance of concrete after collision.

Prediction of Concrete Fragments Amount and Travel Distance under Impact Loading Using Deep Neural Network and Gradient Boosting Method.

In the present study, the amount of fragments generated and their travel distances due to vehicle collision with concrete median barrier (CMB) was analyzed and predicted. In this regard, machine learning was applied to the results of numerical analysis, which were developed by comparing with field test. The numerical model was developed using smoothed particle hydrodynamics (SPH).

Uncertainty Relation for Errors Focusing on General POVM Measurements with an Example of Two-State Quantum Systems.

A novel uncertainty relation for errors of general quantum measurement is presented. The new relation, which is presented in geometric terms for maps representing measurement, is completely operational and can be related directly to tangible measurement outcomes. The relation violates the naïve bound ℏ/2 for the position-momentum measurement, whilst nevertheless respecting Heisenberg's philosophy of the uncertainty principle.

Unilateral pleuroparenchymal fibroelastosis as a rare form of idiopathic interstitial pneumonia: A case report.

Background: Pleuroparenchymal fibroelastosis (PPFE) is a rare idiopathic interstitial pneumonia characterized by predominantly upper lobe involvement with pleural fibrosis and subjacent parenchymal fibrosis. Recently, there have been increasing reports of PPFE, and PPFE might coexist with other interstitial lung diseases in the lower lobe and upper lobe. However, cases of unilateral PPFE are scarce.

Oxidative Methane Conversion to Ethane on Highly Oxidized Pd/CeO Catalysts Below 400 °C.

Methane upgrading into more valuable chemicals has received much attention. Herein, we report oxidative methane conversion to ethane using gaseous O at low temperatures (<400 °C) and atmospheric pressure in a continuous reactor. A highly oxidized Pd deposited on ceria could produce ethane with a productivity as high as 0.

A One-Bag Rapid Desensitization Protocol for Paclitaxel Hypersensitivity: A Noninferior Alternative to a Multi-Bag Rapid Desensitization Protocol.

Background: Desensitization is used to safely continue treatment with a culprit drug in patients with drug hypersensitivity. Currently, a multi-bag protocol is widely used for rapid desensitization, but performing the desensitization procedure is labor intensive as pharmacists and nurses need to prepare and administer diluted solutions. However, it has not been investigated whether dilution is essential for successful desensitization.

Experimental and Numerical Investigation of Deformable Concrete Median Barrier.

In South Korea, the number of vehicles is gradually increasing. The number of heavy vehicles in 2010 increased up to 19% in less than five years. Therefore, the chances of heavy vehicle-concrete median barrier (CMB) collision also became higher than in the past; therefore, a need to study a stricter design level for improving the current CMB (CMB-15) under harsher environments arose.

Clinical implications of discrepant results between genotypic MTBDR and phenotypic Löwenstein-Jensen method for isoniazid or rifampicin drug susceptibility tests in tuberculosis patients.

Background: The widespread use of molecular, genotypic drug susceptibility tests (DSTs) for antituberculosis (anti-TB) drugs has led to the dilemma of interpreting discordant results between genotypic and conventional, phenotypic DSTs. We investigated the clinical characteristics, including treatment patterns and outcomes, of TB patients with a genotype-phenotype discrepancy in susceptibility to isoniazid (INH) or rifampicin (RIF).

Methods: We retrospectively reviewed the medical records of TB patients who had results for 2 DSTs (genotypic method, MTBDR test for INH and RIF, and phenotypic method) treated between August 2010 and October 2016 in a tertiary university hospital.

Modeling and Measurement of Sustained Loading and Temperature-Dependent Deformation of Carbon Fiber-Reinforced Polymer Bonded to Concrete.

This paper aims at presenting the effects of short-term sustained load and temperature on time-dependent deformation of carbon fiber-reinforced polymer (CFRP) bonded to concrete and pull-off strength at room temperature after the sustained loading period. The approach involves experimental and numerical analysis. Single-lap shear specimens were used to evaluate temperature and short-term sustained loading effects on time-dependent behavior under sustained loading and debonding behavior under pull-off loading after a sustained loading period.

Fibulin-3 negatively regulates ALDH1 via c-MET suppression and increases γ-radiation-induced sensitivity in some pancreatic cancer cell lines.

Fibulin-3 (FBLN-3) has been postulated to be either a tumor suppressor or promoter depending on the cell type, and hypermethylation of the FBLN-3 promoter is often associated with human disease, especially cancer. We report that the promoter region of the FBLN-3 was significantly methylated (>95%) in some pancreatic cancer cell lines and thus FBLN-3 was poorly expressed in pancreatic cancer cell lines such as AsPC-1 and MiaPaCa-2. FBLN-3 overexpression significantly down-regulated the cellular level of c-MET and inhibited hepatocyte growth factor-induced c-MET activation, which were closely associated with γ-radiation resistance of cancer cells.

TM4SF4 overexpression in radiation-resistant lung carcinoma cells activates IGF1R via elevation of IGF1.

Transmembrane 4 L six family member 4 (TM4SF4) is a member of the tetraspanin L6 domain family. Other members of this family, TM4SF1 (also known as L6-Ag) and TM4SF5, have been shown to be upregulated in multiple tumors and involved in epithelial-to-mesenchymal transition and cell migration. However, unlike its homologs, little is known about TM4SF4.