Treatment of duodenal ulcer with a long-acting synthetic secretin: a pilot trial.

In three male duodenal ulcer patients, the effects of a 4-week treatment with a long-acting synthetic secretin -- daily s.c. administrations of 10 clinical units secretin/kg b.

[Pancreatic response to graded doses of synthetic secretion: comparison between intravenous and pernasal administration in man].

The response of the human pancreas to varying doses of pure synthetic secretin administered intravenously and, for comparison, 8 days later in the form of snuff was examined, intraindividually, in 10 healthy test subjects. After intubation of the stomach and duodenum and continuous instillation of radioactive vitamin B12, the recovery rate of the marker substance was measured in duodenal aspirates and employed to compute the pancreatic bicarbonate and enzyme outputs. The dose-response relationship between pancreatic bicarbonate production and varying doses of synthetic secretin administered intravenously and in the form of snuff, was good.

Analysis of the motor effects of 13-norleucine motilin on the rabbit, guinea pig, rat, and human alimentary tract in vitro.

Motor effects of 13-norleucine motilin (13-Nle-M), a synthetic analog of motilin and biologically equivalent to the natural polypeptide, on the rabbit, guinea pig, rat, and human alimentary tract were investigated in vitro. Whereas guinea pig and rat preparations proved refractory to 13-Nle-M action, muscle strips of the stomach and upper small intestine from rabbits and man were highly sensitive to 13-Nle-M, contractile responses being elicited with concentrations of less than 2 times 10-minus 9 M. Although circular muscle from rabbit colon responded to 13-Nle-M, Taenia coli preparations were unaffected by the polypeptide; in man, the reverse was observed.

Effects of 13-nle-motilin in man--inhibition of gastric evacuation and stimulation of pepsin secretion.

In 3 healthy male volunteers, graded doses of 13-norleucine-motilin (13-nle-motilin)--synthetic analogue of motilin and biologically equivalent to the natural polypeptide--were given intravenously on separate days. Gastric emptying, as determined by means of a radioisotope method, was slowed down dose-dependently by increasing doses of 13-nle-motilin. This was indicated by increasing "half-lives" and "starting indices" of the gastric emptying process, and by decreasing pyloric loss rates, respectively.