The role of dorsomedial striatum adenosine 2A receptors in the loss of goal-directed behaviour.

Rationale: Adenosine A receptors (AR) in the dorsal striatum have been implicated in goal-directed behaviour. While activation of these receptors with several methods has resulted in an insensitivity to outcome devaluation, particular explanations for how they disrupt behaviour have not been explored. We both confirm a role for A receptors in goal-directed responding and evaluate additional behavioural aspects of goal-directed control to more fully understand the role of A receptors in instrumental behaviour.