Publications by authors named "Jaeboum Youm"
Carbonic anhydrase enzymes (CAs) catalyse the reversible hydration of CO2 to H+ and HCO3- ions. This catalysis is proposed to be harnessed by acid/base transporters, to facilitate their transmembrane flux activity, either through direct protein-protein binding (a 'transport metabolon') or local functional interaction. Flux facilitation has previously been investigated by heterologous co-expression of relevant proteins in host cell lines/oocytes.
View Article and Find Full Text PDFCa(2+) signaling regulates cell function. This is subject to modulation by H(+) ions that are universal end-products of metabolism. Due to slow diffusion and common buffers, changes in cytoplasmic [Ca(2+)] ([Ca(2+)]i) or [H(+)] ([H(+)]i) can become compartmentalized, leading potentially to complex spatial Ca(2+)/H(+) coupling.
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- * The balance between GCs and the glucocorticoid receptor II (GR) is essential for their functionality, while both the nucleus and mitochondria must work together to ensure efficient cellular responses and mitochondrial health.
- * Research is exploring how GCs can directly and indirectly regulate mitochondrial gene expression, revealing that GRs in mitochondria and glucocorticoid response elements (GREs) in mitochondrial DNA play significant roles in this regulation.