ATG101 Degradation by HUWE1-Mediated Ubiquitination Impairs Autophagy and Reduces Survival in Cancer Cells.

Autophagy is a critical cytoprotective mechanism against stress, which is initiated by the protein kinase Unc-51-like kinase 1 (ULK1) complex. Autophagy plays a role in both inhibiting the progression of diseases and facilitating pathogenesis, so it is critical to elucidate the mechanisms regulating individual components of the autophagy machinery under various conditions. Here, we examined whether ULK1 complex component autophagy-related protein 101 (ATG101) is downregulated via ubiquitination, and whether this in turn suppresses autophagy activity in cancer cells.

Cubic Convolution Scaler Optimized for Local Property of Image Data.

A scaler is one of the most important modules in various video applications, such as ultra-high definition TV and scalable video systems. A variety of scaling techniques have been used to increase the video quality when the resolution of the source image has to be up- and down-scaled. Some conventional schemes exploit the property of local block data.