Publications by authors named "JaeHun Jung"

We analyzed the publication and submission statuses of Korean medical journals from 2010 to 2024, amidst challenges impacting researchers. Data from 58 domestic journals identified through the 2023 JCR database were used to assess publication status, while data from the () were utilized to examine submission status. The proportion of published original articles by domestic authors decreased by 3% in 2024 compared to 2023.

View Article and Find Full Text PDF

Purpose: Although surgical procedures including robotic surgery in radical prostatectomy have evolved, urinary incontinence after surgery are still not resolved. This study was to evaluate the risk of clinically significant incontinence after radical prostatectomy according to various procedural types.

Materials And Methods: The retrospective cohort study included prostate cancer (n=14,484) in South Korea between 2002 and 2017 as shown in the National Health Insurance Data.

View Article and Find Full Text PDF

Purpose: To assess whether an artificial intelligence (AI)-based reassurance-call can inform patients about potential complications and provides reassurance following a prostate biopsy.

Materials And Methods: From October 2022 to December 2023, 42 patients aged 40 to 70 years undergoing their first prostate biopsy were recruited. The 'Reassurance-call' service was utilized to inform and monitor patients for complications.

View Article and Find Full Text PDF

Introduction: Coronavirus 2019 (COVID-19) vaccination rates in pregnant women remain low owing to safety concerns. When evaluating vaccine safety, comparisons with unvaccinated individuals may lead to healthy vaccinee bias. This study aimed to investigate the association between mRNA-based COVID-19 vaccination and pregnancy-related adverse outcomes compared with influenza vaccination.

View Article and Find Full Text PDF

Background: Despite the proven effectiveness of oral antivirals against severe acute respiratory syndrome coronavirus 2 in randomized trials, their clinical reevaluation is vital in the context of widespread immunity and milder prevalent variants. This study aimed to assess the effectiveness of oral antivirals for coronavirus disease 2019 (COVID-19).

Methods: This retrospective cohort study utilized a target trial emulation framework to analyze patients with COVID-19 aged 60+ from January to December 2022.

View Article and Find Full Text PDF

Background: There is a dearth of research on the factors linked with adverse events (AEs) associated with nirmatrelvir/ritonavir (NMVr) and molnupiravir (MOL), particularly in the elderly. Therefore, this study aimed to investigate self-reported AEs and identify factors associated with the occurrence of AEs following NMVr or MOL treatment among survey participants aged 60 years or older in South Korea.

Methods: This nationwide survey was conducted through in-person interviews using structured questionnaires, from July 24 to August 31, 2023.

View Article and Find Full Text PDF
Article Synopsis
  • A study was conducted to evaluate the safety of COVID-19 treatments nirmatrelvir/ritonavir (NMVr) and molnupiravir (MOL) by comparing acute complications in treated versus untreated patients.
  • Data from nationwide databases were used to analyze results from over 700,000 NMVr users and over 150,000 MOL users, focusing on specific cardiac and neurological events.
  • The findings revealed that both NMVr and MOL users had a lower risk of certain serious side effects like atrial fibrillation and dysgeusia, suggesting these treatments may be effective in reducing acute complications linked to COVID-19.
View Article and Find Full Text PDF
Article Synopsis
  • A study was conducted to explore the relationship between COVID-19 and pneumothorax in hospitalized patients, comparing it to influenza cases.
  • The research involved 46,460 COVID-19 patients and 6,117 influenza patients, finding a pneumothorax occurrence rate of 0.74% in COVID-19 cases.
  • Overall, COVID-19 does not significantly increase the risk of pneumothorax compared to influenza, but it poses a higher risk in patients without chronic lung diseases.
View Article and Find Full Text PDF
Article Synopsis
  • - The study aimed to uncover unique protein markers associated with ocular graft-versus-host disease (GVHD) by analyzing corneal samples from GVHD model mice and control mice four weeks post-bone marrow transplantation.
  • - Researchers conducted proteomic analysis and identified key protein pathways upregulated in GVHD, including necroptosis, MAPK, and neutrophil extracellular trap pathways, along with newly upregulated molecules involved in these processes.
  • - The findings could provide insights into the mechanisms behind ocular GVHD and pave the way for developing new therapies targeting corneal issues in affected patients.
View Article and Find Full Text PDF
Article Synopsis
  • Patients with kidney disease are more vulnerable to COVID-19, even after vaccination, compared to those without kidney disease.
  • A study utilized a large Korean COVID-19 registry and NHIS claims data to analyze the risk of infection and severe outcomes among vaccinated and unvaccinated individuals with and without kidney disease.
  • Results indicated that kidney disease patients experienced higher risks of COVID-19 infection and severe health complications post-infection, emphasizing the need for continued vigilance in their care post-vaccination.
View Article and Find Full Text PDF
Article Synopsis
  • A recent study highlighted that COVID-19 patients have a heightened risk of severe cardiovascular issues, particularly pulmonary embolism (PE) and deep vein thrombosis (DVT)!
  • The research analyzed data from over 1.6 million COVID-19 patients compared to over 14 million non-infected individuals in South Korea from January 2021 to March 2022!
  • Results indicated a significantly higher risk of PE (6.25 times) and DVT (3.05 times) in unvaccinated COVID-19 patients, while vaccinated individuals still faced a higher risk for PE but not DVT!
View Article and Find Full Text PDF

Background: Human adenovirus (HAdV) is a prevalent causative agent of acute respiratory disease (ARD) and is frequently responsible for outbreaks, particularly in military environments. Current vaccines do not effectively cover HAdV subtypes commonly found among Korean military personnel, highlighting the need for a new targeted vaccine. This study presents a cost-benefit analysis to evaluate the economic viability of developing and implementing such a vaccine within a military context.

View Article and Find Full Text PDF

We aimed to examine the impact of COVID-19 non-pharmaceutical interventions (NPIs) on the relationship between air pollutants and hospital admissions for respiratory and non-respiratory diseases in six metropolitan cities in South Korea. This study compared the associations between particulate matter (PM and PM) and hospital admission for respiratory and non-respiratory diseases before (2016-2019) and during (2020) the implementation of COVID-19 NPIs by using distributed lag non-linear models. In the Pre-COVID-19 period, the association between PM and admission risk for asthma and COPD showed an inverted U-shaped pattern.

View Article and Find Full Text PDF
Article Synopsis
  • - The COVID-19 Vaccine Safety Research Committee (CoVaSC) was formed in November 2021 to gather independent data on adverse events related to COVID-19 vaccinations, led by Korea's National Academy of Medicine and requested by the Korea Disease Control and Prevention Agency.
  • - In September 2022, the COVID-19 Vaccine Safety Research Center was established, restructuring CoVaSC into four specialized departments focused on research, communication, and policy regarding vaccine safety.
  • - The center has conducted comprehensive studies on 27 adverse events, involving collaboration between experts and regular updates to the public, while planning to enhance its research efforts and maintain transparency in its findings.
View Article and Find Full Text PDF

Purpose: Androgen signaling is associated with various secondary cancer, which could be promising for potential treatment using androgen deprivation therapy (ADT). This study investigated whether ADT use was associated with secondary cancers other than prostate cancer in a nationwide population-based cohort.

Materials And Methods: A total, 278,434 men with newly diagnosed prostate cancer between January 1, 2002 and December 31, 2017 were identified.

View Article and Find Full Text PDF

This chapter explores advanced single-molecule techniques for studying protein-DNA interactions, particularly focusing on Replication Protein A (RPA) using a force-fluorescence setup. It combines magnetic tweezers (MT) with total internal reflection fluorescence (TIRF) microscopy, enabling detailed observation of DNA behavior under mechanical stress. The chapter details the use of DNA hairpins and bare DNA to examine RPA's binding dynamics and its influence on DNA's mechanical properties.

View Article and Find Full Text PDF

Background: The current physical activity guidelines recommend engagement in strength activities at least 2 days per week. Currently, there is a lack of literature examining strength activities among people with disabilities. The purpose of this study is to estimate and compare the prevalence of engagement in strength activities and adherence to strength activity guidelines among adults with and without disabilities in the United States.

View Article and Find Full Text PDF
Article Synopsis
  • A large-scale study analyzed data from over 2 million COVID-19 patients to investigate the short-term incidence of pneumonia post-infection and how vaccinations affect this risk across different SARS-CoV-2 variants.
  • The results indicated significant reductions in pneumonia risk for vaccinated individuals, with those receiving multiple doses showing even greater protection, particularly against newer variants.
  • Overall, receiving the second and third doses of the vaccine provided a substantial decrease in the likelihood of developing pneumonia compared to unvaccinated individuals.
View Article and Find Full Text PDF
Article Synopsis
  • The study aimed to evaluate how receiving primary and third doses of the COVID-19 vaccine influenced the risk of long-term health issues following infection.
  • Using data from South Korea, researchers tracked over 8 million vaccinated individuals and nearly 400,000 unvaccinated individuals for 30-120 days after COVID-19 infection, focusing on 26 specific health conditions.
  • Results indicated that vaccination, especially with three doses, significantly reduced the risks of various health problems, supporting the idea that vaccines can help lessen the long-term effects of COVID-19.
View Article and Find Full Text PDF
Article Synopsis
  • Human adenovirus (HAdV) is a prevalent cause of acute respiratory disease in the Korean military, raising concerns about its impact on soldier health.
  • An analysis of data from over 23,000 patients revealed that 44.78% tested positive for respiratory viruses, with HAdV being the most common, affecting 8,580 individuals.
  • HAdV-infected patients experienced more healthcare utilization and severe outcomes, including higher rates of pneumonia, longer hospital stays, and the need for advanced treatments compared to non-HAdV-infected patients.
View Article and Find Full Text PDF
Article Synopsis
  • - The study aimed to compare the occurrence of adverse events of special interest (AESIs) between two types of COVID-19 vaccines: adenoviral vector-based (ChAdOx1) and mRNA-based (BNT162b2 or mRNA-1273).
  • - Researchers analyzed data from the National Health Insurance Service database, finding that both vaccine types had low incidences of AESIs, but noted higher rates of certain heart-related issues in those who received mRNA vaccines.
  • - Key findings highlighted significant differences in safety profiles between the two vaccine platforms, especially regarding myocarditis and Guillain-Barré syndrome, while overall adverse event risks were low for both.
View Article and Find Full Text PDF

Background: Solid organ transplant recipients (SOTRs) are at higher risk for severe infection. However, the risk for severe COVID-19 and vaccine effectiveness among SOTRs remain unclear.

Methods: This retrospective study used a nationwide health care claims database and COVID-19 registry from the Republic of Korea (2020 to 2022).

View Article and Find Full Text PDF

Background: Postpancreatectomy diabetes can be caused by resection of functioning pancreatic tissue and is associated with postoperative pancreatic islet cell mass loss and subsequent endocrine dysfunction. Diabetes is a well-known risk factor for ischemic heart disease. However, no previous studies have investigated ischemic heart disease in patients with postpancreatectomy diabetes and pancreatic cancer.

View Article and Find Full Text PDF