Publications by authors named "Jae-Suk Park"
Article Synopsis
- High-intensity statin therapy is effective in reducing mortality and cardiovascular events in patients with atherosclerotic cardiovascular disease (ASCVD), but elderly patients often tolerate moderate-intensity statins better due to intolerance risks.
- A study compared the incidence of statin-associated muscle symptoms (SAMS) and low-density lipoprotein cholesterol (LDL-C) levels in elderly ASCVD patients on either high-intensity statins or moderate-intensity statins combined with ezetimibe.
- Results showed that combination therapy significantly reduced SAMS (0.7% vs 5.7%) while achieving comparable LDL-C target levels (75.4% vs 68.7%), indicating that moderate-intensity therapy with ezetim
Article Synopsis
- - Our research explores how auxiliary structures can improve ion transport in electrochemical systems like batteries and desalination units, which are crucial for sustainable development.
- - We found that the placement of these structures, modeled as pillar arrays, affects ion transfer efficiency depending on the depth of the microchannel and their proximity to ion-selective surfaces.
- - The study demonstrates that spatial arrangement is key in enhancing performance and could inform future designs for devices such as fuel cells and desalination systems.
Article Synopsis
- The study focused on improving shockwave lithotripsy, a treatment for kidney stones, by considering how breathing affects targeting and safety.
- They used a device to mimic kidney movement during breathing and tested artificial stones in a gel, measuring changes after shockwave exposure, along with clinical trials on patients wearing respiratory masks.
- Results showed better treatment efficiency with regular breathing patterns, a 65.6% success rate in regular breathers compared to 40% in irregular breathers, suggesting that managing breathing can enhance the lithotripsy process and reduce patient discomfort.
Background: Current guidelines recommend that patients with established atherosclerotic cardiovascular disease (ASCVD) use high-intensity statin therapy to lower low-density lipoprotein (LDL)-cholesterol levels by at least 50%, irrespective of age. However, in real-world practice, there is reluctance to maintain statin use in response to side-effects, particularly statin-associated muscle symptoms (SAMS). Moreover, no randomized trial has been conducted on the safety of statin therapy in elderly patients.
View Article and Find Full Text PDFPurpose: This study aimed to compare the functional and oncological outcomes of females who underwent uterus-sparing radical cystectomy (USRC) and standard radical cystectomy (SRC).
Materials And Methods: Between February 2009 and December 2020, 90 female patients who underwent radical cystectomy with urinary diversion were included in this study, comprising the USRC and SRC groups. Functional outcomes were assessed in 63 patients who only underwent radical cystectomy with neobladder formation.
Article Synopsis
- This study investigates the causes of high intrarenal pressure (IRP) during minimally invasive surgery for kidney stones, as excessive IRP can lead to complications due to bacteria absorption.* -
- It analyzed data from 27 patients undergoing mini-PCNL, finding that IRP significantly increased during specific surgical phases like stone fragmentation and upper-pole navigation.* -
- Factors influencing elevated IRP included baseline pressure, surgical technique, number of stones, and laser settings; the study suggests table tilting may help manage IRP in some cases.*
Purpose: We aimed to identify risk factors for transurethral coagulation (TUC) using bipolar electrocautery for hemostasis during holmium laser enucleation of the prostate (HoLEP) surgery for benign prostatic hyperplasia (BPH).
Methods: We analyzed the clinical outcomes of HoLEP surgery performed by a single surgeon between January 2010 and April 2020 at the Seoul National University Hospital. Patient characteristics and perioperative parameters were used to identify the risk factors for TUC.
Rapid and accurate nanoelectrokinetic diagnosis of drug-resistant bacteria.
Biosens Bioelectron
October 2022
Article Synopsis
- * The newly developed Rapid and Accurate Nanoelectrokinetic Diagnostic System (RANDx) can detect drug-resistant bacteria within just 7 minutes by using a nanoelectrokinetic paper-based device (NEK-PAD) that enhances sample preparation.
- * RANDx utilizes a unique design that enables significant preconcentration of bacteria and extraction of drug-resistant enzymes, allowing for the detection of bacteria at low concentrations without extra labeling, thus showing promise for use in remote medical settings.
Article Synopsis
- The containment liner plate (CLP) in nuclear power plants is crucial for shielding against environmental threats and preventing radioactive leaks in case of accidents, composed of various materials like liner plates, reinforcing bars, tendons, and concrete.
- Recently, issues such as corrosion on the rear side of the liner plate and the presence of concrete voids have been identified as serious defects in South Korean nuclear power plants.
- The study introduced a new inspection method combining phased array ultrasonic testing and acoustic resonance techniques to detect defects, alongside a proposed automated inspection system for the CLP.
Background: , considered to be an environmental organism, is a rare cause of human infections. Although in recent years the frequency of infections reported in the literature has increased, few cases of pneumonia caused by have been described. Here, we investigate the clinical characteristics, management, and clinical outcomes of pneumonia caused by .
View Article and Find Full Text PDFControllable pH Manipulations in Micro/Nanofluidic Device Using Nanoscale Electrokinetics.
Micromachines (Basel)
April 2020
Article Synopsis
- A new nanoscale phenomenon called ion concentration polarization (ICP) causes significant pH changes in fluid samples, prompting research into its origins and management strategies.
- * Instead of negating these pH changes, the study explores how to harness them, such as creating controlled pH gradients by applying electric current through a proton exchange membrane.
- * The research also shows that the pH level can be monitored using pH-responsive hydrogels, which act as barriers in microchannels depending on whether the pH is above or below a certain threshold, leading to potential applications in localized pH stimulation and portable pH sensing.
Dielectric microstructures have been reported to have a negative influence on permselective ion transportation because ions do not migrate in areas where the structures are located. However, the structure can promote the transportation if the membrane is confined to a microscopic scale. In such a scale where the area to volume ratio is significantly large, the primary driving mechanisms of the ion transportation transition from electro-convective instability (EOI) to surface conduction (SC) and electroosmotic flow (EOF).
View Article and Find Full Text PDFArticle Synopsis
- * The classification of conjoined nerve roots depends on their origin, either from an unexpected spinal level or an anastomotic branch.
- * Preoperative identification of these anomalies is crucial for successful surgeries and minimizing the risk of accidental nerve damage.
Precision thermometry of the skin can, together with other measurements, provide clinically relevant information about cardiovascular health, cognitive state, malignancy and many other important aspects of human physiology. Here, we introduce an ultrathin, compliant skin-like sensor/actuator technology that can pliably laminate onto the epidermis to provide continuous, accurate thermal characterizations that are unavailable with other methods. Examples include non-invasive spatial mapping of skin temperature with millikelvin precision, and simultaneous quantitative assessment of tissue thermal conductivity.
View Article and Find Full Text PDFStudy Design: A retrospective outcome study.
Objective: The purpose of this study was to analyze the clinical outcomes of our experience with the C2 translaminar screw technique and evaluate its feasibility as an alternative or salvage of the pedicle screw.
Summary Of Background Data: Pedicle screws are the most biomechanically stable screws for use in atlantoaxial fixation.
Article Synopsis
- - The study aimed to explore how strain rate (SR) imaging correlates with coronary flow reserve (CFR) in evaluating the health of heart muscle after a heart attack.
- - In a group of 40 patients post-heart attack, it was found that patients with viable but akinetic heart muscle had higher SR and CFR measurements compared to those with nonviable muscle.
- - The results indicate that SR imaging can effectively predict the viability of heart muscle, showing a strong relationship with the CFR, thus offering a noninvasive assessment method after an acute myocardial infarction.
Objective: Remote cerebellar hemorrhage (RCH) is one of the rare complications occurring after supratentorial surgery, and its pathomechanism is poorly understood. We report 10 cases of RCH from our institution and review 154 cases from a database in order to delineate incidence, common presentation, risk factors, and outcomes of this complication. In addition, the means of prevention are discussed.
View Article and Find Full Text PDFBackground: The effect of atorvastatin 10 mg vs 40 mg in clopidogrel resistance and clinical events after coronary stenting was compared in patients with acute coronary syndrome (ACS).
Methods And Results: Platelet aggregation was measured before clopidogrel administration and 4 h, 24 h, 5 days, and 8 months later in 130 ACS patients. Stented patients were randomly assigned to atorvastatin either 10 mg (n=65) or 40 mg (n=65), and received an oral loading dose of 300 mg of clopidogrel followed by 75 mg/day for 8 months.
Article Synopsis
- * Research shows that GRbeta does not act as a dominant negative inhibitor of the wild type GRalpha but has its own functional role, particularly in the context of glucocorticoid effects on IL-8 release in airway cells.
- * GRbeta can inhibit glucocorticoid-mediated transcriptional activation and decrease histone acetylation at the IL-8 promoter, but it does not alter the suppressive effects of glucocorticoids on IL-8 expression, suggesting a
We showed previously that anharmonic DNA dynamical features correlate with transcriptional activity in selected viral promoters, and hypothesized that areas of DNA softness may represent loci of functional significance. The nine known promoters from human adenovirus type 5 were analyzed for inherent DNA softness using the Peyrard-Bishop-Dauxois model and a statistical mechanics approach, using a transfer integral operator. We found a loosely defined pattern of softness peaks distributed both upstream and downstream of the transcriptional start sites, and that early transcriptional regions tended to be softer than late promoter regions.
View Article and Find Full Text PDFArticle Synopsis
- Researchers developed a multi-wavelength fiber ring laser that can switch individual wavelengths on and off using advanced semiconductor optical amplifiers and unique filters.
- The filters are designed with a fiber Sagnac loop interferometer that combines fiber Bragg gratings and a polarization controller to achieve this switching.
- This laser system offers strong performance, allowing for independent control of different wavelengths and high-quality output, making it suitable for applications like wavelength-division multiplexing.