Marital satisfaction and its impact on frailty in Korean older adults: a longitudinal analysis.

Background: Despite a wealth of literature on marital dissatisfaction and adverse health outcomes, little is known about the relationship between marital dissatisfaction and frailty in older adults.

Methods: This longitudinal study utilised the data of 11 174 individuals who participated in the biennial Korean Longitudinal Study of Ageing survey from 2006 to 2020 and were aged ≥45 during the initial wave. Frailty was measured using a frailty instrument, which utilised exhaustion, social isolation, and handgrip strength weakness.

The Association Between Psychological Resilience and Spiritual Well-Being Among Family Caregivers of Terminally Ill Cancer Patients: A Multicenter Cross-Sectional Study.

This study was undertaken to determine the nature of the relationship between psychological resilience and spiritual well-being (SWB) among family caregivers (FCs) of patients with terminal cancer. This multicenter cross-sectional study included 173 FCs from nine inpatient hospice care units. SWB was assessed using the Functional Assessment of Chronic Illness Therapy-Spiritual well-being questionnaire, and various psychosocial variables, including psychological resilience, were also measured.

Effectiveness of cyclosporine nanoemulsion eye drops in patients with mild-to-moderate dry eyes: objective and subjective evaluation.

Background: To compare and evaluate objective and subjective clinical parameters between 0.05% cyclosporine nanoemulsion (CsN) and 0.15% hyaluronic acid (HA) administration in patients with mild-to-moderate dry eyes.

Atomically Thin Two-Dimensional Kagome Flat Band on the Silicon Surface.

In condensed matter physics, the Kagome lattice and its inherent flat bands have attracted considerable attention for their prediction and observation to host a variety of exotic physical phenomena. Despite extensive efforts to fabricate thin films of Kagome materials aimed at modulating flat bands through electrostatic gating or strain manipulation, progress has been limited. Here, we report the observation of a d-orbital hybridized Kagome-derived flat band in Ag/Si(111) as revealed by angle-resolved photoemission spectroscopy.

Ecosystem service evaluation based on local knowledge of residents using spatial text-mining.

This study aims to evaluate the ecosystem services of Upo wetland, one of the best-known Ramsar sites in Korea, reflecting the characteristics of the ecological assets and local knowledges in the area. Application of spatial text-mining begins with collecting local perceptions and knowledge of residents on the 17 ecological assets of Upo site and surrounding area. Our results identified five important ecosystem services: flood control during heavy rainfall, water purification by aquatic plants, cultural and natural heritages, agricultural products and water provision for crop cultivation.

Maternal Gliadin Intake Reduces Oocyte Quality with Chromosomal Aberrations and Increases Embryonic Lethality through Oxidative Stress in a Model.

Oocyte quality is essential for reproductive capacity, but it rapidly declines with age. In addition to aging, maternal nutrition is a major concern in maintaining oocyte quality. Gliadin, a major component of gluten, causes gluten toxicity, which has been reported in a variety of gluten-related disorders.

Mental Health of Adolescents and Subjective Economic Deterioration Caused by COVID-19 in Korea.

Background: The coronavirus disease 2019 (COVID-19) pandemic greatly impacted the health and economy worldwide. Children and adolescents are less affected by COVID-19 but are more vulnerable to secondary damage, such as mental health. We would like to evaluate the subjective economic changes caused by COVID-19 in Korea and adolescents' mental health status.

Effect of preoperative eyedrops on cytokine concentrations in aqueous humor of patients undergoing femtosecond laser-assisted cataract surgery.

Purpose: To compare the anti-inflammatory activity of preoperatively applied eyedrops, as determined by cytokine concentrations in aqueous humor collected during surgery in patients undergoing femtosecond laser-assisted cataract surgery.

Methods: A total of 120 patients undergoing femtosecond laser-assisted cataract surgery were randomly assigned to four groups of 30 patients each. Groups were administered 0.

Clinical Outcomes after Mix-and-Match Implantation of Extended Depth of Focus and Diffractive Multifocal Intraocular Lenses.

Purpose: To evaluate the clinical outcomes after bilateral mix-and-match cataract surgery using extended depth of focus (EDOF) and diffractive multifocal (DMF) intraocular lenses (IOLs). . Asan Medical Center, Seoul, South Korea.

Clinical outcomes of a monofocal intraocular lens with enhanced intermediate function compared with an extended depth-of-focus intraocular lens.

Purpose: To compare clinical outcomes of a new monofocal intraocular lens (IOL) with enhanced intermediate function and an extended depth-of-focus (EDoF) IOL.

Setting: Asan Medical Center, Seoul, Korea.

Design: Nonrandomized prospective comparative case series.

Effects of lid debris debridement combined with meibomian gland expression on the ocular surface MMP-9 levels and clinical outcomes in moderate and severe meibomian gland dysfunction.

Background: To evaluate the effects of lid debris debridement and meibomian gland expression (MGX) on extracellular matrix metalloproteinase-9 (MMP-9) levels and clinical outcomes of moderate and severe MGD.

Methods: In this retrospective case series study, a total 48 eyes of 24 patients with moderate and severe MGD underwent one session of lid debris debridement using the BlephEx combined with MGX. We evaluated the tear film break-up time (TBUT), corneal and conjunctival fluorescein staining scores, Schirmer 1 test, biomicroscopic examination of lid margins and meibomian gland (MG), ocular surface disease index (OSDI) questionnaire score, and extracellular MMP-9 levels using a point-of-care MMP-9 immunoassay device before and 4 weeks after lid debris debridement and MGX.

Evaluation of Astigmatic Correction Using Vector Analysis after Combined Femtosecond Laser-Assisted Phacoemulsification and Intrastromal Arcuate Keratotomy.

The aim of this study was to evaluate astigmatic correction in patients with mild to moderate astigmatism after combined femtosecond laser-assisted cataract surgery (FLACS) and intrastromal arcuate keratotomy (ISAK), using vector analysis. This retrospective study included patients with corneal astigmatism of 0.5-3.

Novel Findings about Myopia in Patients with Oculodermal Melanocytosis (Nevus of Ota).

: To test the hypothesis that ocular pigment in patients with oculodermal melanocytosis decreases myopia severity.: Refractive and biometric parameters were measured and compared between pigmented eyes and non-pigmented contralateral eyes in oculodermal melanocytosis patients that underwent surgical ocular pigmentation removal. To assess pigmentation, the pigmentation score was measured in each quadrant of the sclera and added together for a cumulative score.

Setting the governance of a participatory ecosystem service assessment based on text mining the language of stakeholders' opinions.

The resident participatory ecosystem service assessment is a method for determining local situations through the ecological knowledge of residents who most closely experience changes in local ecosystems. This is an opportunity for residents to synthesize their environmental knowledge. It provides valuable research material for researchers, can be utilized as a pathway for civil servants to reflect residents' opinions on policy, and can help environmental organizations instill environmental awareness and develop environmental public opinions in residents.

Transplantation of human corneal limbal epithelial cell sheet harvested on synthesized carboxymethyl cellulose and dopamine in a limbal stem cell deficiency.

This study aimed to evaluate the efficacy and safety of transplantation with human corneal limbal epithelial (HCLE) cell sheets cultured on carboxymethyl cellulose (CMC)-dopamine (DA)-coated substrates and harvested via enzymatic digestion of CMC with cellulase in a rabbit animal model of limbal stem cell deficiency (LSCD). Synthesized CMC-DA was pretreated onto the surface of culture plates. Then, HCLE cells were cultured on precoated CMC-DA and HCLE cell sheets were harvested using cellulase-containing cell culture medium.

Changes in the expression of matrix metalloproteinase-9 after intense pulsed light therapy combined with meibomian gland expression in moderate and severe meibomian gland dysfunction.

Purpose: To evaluate the combined effect of intense pulsed light (IPL) therapy and meibomian gland expression on extracellular matrix metalloproteinase-9 (MMP-9) levels and clinical outcomes of moderate and severe meibomian gland dysfunction (MGD) treatment.

Methods: This retrospective study was conducted on 45 eyes of 23 patients with moderate and severe MGD. Each eye underwent three IPL sessions and meibomian gland expression at 2-week intervals.

Clinical outcomes after mix-and-match implantation of diffractive multifocal intraocular lenses with + 2.75 and + 4.00 diopter add powers.

Background: To evaluate the clinical outcomes of bilateral mix-and-match implantation of diffractive multifocal intraocular lenses (IOLs) with different add powers.

Methods: We retrospectively reviewed the medical records of 18 patients who underwent bilateral mix-and-match implantation of diffractive multifocal IOLs with different add powers. Multifocal IOLs with add powers of + 2.

Protective Effects of Cyclosporine A Emulsion Versus Cyclosporine A Cationic Emulsion Against Desiccation Stress in Human Corneal Epithelial Cells.

Purpose: To compare the protective effects of cyclosporine A emulsion (Restasis: 0.05% cyclosporine A) (CsAE) and cyclosporine A cationic emulsion (Ikervis: 0.1% cyclosporine A) (CsACE) on cellular inflammation, apoptosis, proliferation, and survival in an in vitro dry eye model.

Antifibrotic Effects of Sakuraso-Saponin in Primary Cultured Pterygium Fibroblasts in Comparison With Mitomycin C.

Purpose: To investigate the antifibrotic effects of sakuraso-saponin on a primary culture of human pterygium fibroblasts (HPFs) and normal human Tenon fibroblasts (HTFs) as compared to the effects of mitomycin C (MMC).

Methods: Samples of HPFs and HTFs were acquired during primary pterygium surgery. Cell toxicity, cell migration, and expression of α-smooth muscle actin (α-SMA) and transforming growth factor-β (TGF-β) were evaluated in HPFs and HTFs after treatment with sakuraso-saponin and MMC.

Comparison of Color Light-Emitting Diode Corneal Topographer and Dual Rotating Scheimpflug-Placido Topographer.

Purpose: To compare measurements of anterior and posterior keratometric values, using a color light-emitting diode corneal topographer and a dual rotating Scheimpflug-Placido topographer.

Methods: Anterior and posterior corneal index measurements were performed using a color light-emitting diode corneal topographer (Cassini) and a dual rotating Scheimpflug-Placido topographer (Galilei G4) and then compared. The paired -test, intraclass correlation coefficients (ICCs), and Bland-Altman plots were used to evaluate the agreement between measurements.

Proteogenomic Characterization of Human Early-Onset Gastric Cancer.

We report proteogenomic analysis of diffuse gastric cancers (GCs) in young populations. Phosphoproteome data elucidated signaling pathways associated with somatic mutations based on mutation-phosphorylation correlations. Moreover, correlations between mRNA and protein abundances provided potential oncogenes and tumor suppressors associated with patient survival.