Multifunctional hydrogel nano-probes for atomic force microscopy.

Since the invention of the atomic force microscope (AFM) three decades ago, there have been numerous advances in its measurement capabilities. Curiously, throughout these developments, the fundamental nature of the force-sensing probe-the key actuating element-has remained largely unchanged. It is produced by long-established microfabrication etching strategies and typically composed of silicon-based materials.

Advanced adipose-derived stem cell protein extracts with antioxidant activity modulates matrix metalloproteinases in human dermal fibroblasts.

Advanced adipose-derived stem cell protein extracts (AAPE) were used instead of live stem cells to investigate their effect on oxidative stress and matrix metalloproteinases (MMPs) related to tissue repair in human dermal fibroblasts (HDFs). In this study, it was observed that AAPE at 2μg/ml specifically exhibited scavenging activity of hydrogen peroxide and reducing power. The inhibitory effect of AAPE at 2μg/ml on MMP-2 activity was increased in the presence of phorbol myristate acetate (PMA).

The effect of secretory factors of adipose-derived stem cells on human keratinocytes.

Unlabelled: The beneficial effects of adipose-derived stem cell conditioned medium (ADSC-CM) on skin regeneration have been reported. Although the mechanism of how ADSC-CM promotes skin regeneration is unclear, ADSC-CM contained various growth factors and it is an excellent raw material for skin treatment. ADSC-CM produced in a hypoxia condition of ADSC-in other words, Advanced Adipose-Derived Stem cell Protein Extract (AAPE)-has great merits for skin regeneration.