Publications by authors named "Jae I Shin"
Objective: To identify the COVID-19 pandemic impact on well-being/mental health, coping strategies, and risk factors in adolescents worldwide.
Method: This study was based on an anonymous online multi-national/multi-language survey in the general population (representative/weighted non-representative samples, 14-17 years of age), measuring change in well-being (World Health Organization-Five Well-Being Index [WHO-5]/range = 0-100) and psychopathology (validated composite P-score/range = 0-100), WHO-5 <50 and <29, pre- vs during COVID-19 pandemic (April 26, 2020-June 26, 2022). Coping strategies and 9 a priori- defined individual/cumulative risk factors were measured.
Background: Regional gray matter volume (GMV) differences between individuals with mental disorders and comparison participants may be confounded by co-occurring disorders. To disentangle disorder-specific GMV correlates, we conducted a large-scale multidisorder meta-analysis using a novel approach that explicitly models co-occurring disorders.
Methods: We systematically reviewed voxel-based morphometry studies indexed in PubMed and Scopus up to January 2023 that compared adults with major mental disorders (anorexia nervosa, schizophrenia spectrum, anxiety, bipolar, major depressive, obsessive-compulsive, and posttraumatic stress disorders plus attention-deficit/hyperactivity, autism spectrum, and borderline personality disorders) with comparison participants.
Article Synopsis
- - The study investigates the link between dynapenic abdominal obesity (DAO) and disability in daily living activities among older adults in low- and middle-income countries, finding DAO increases the risk of disability by over twice compared to those without it.
- - Based on data from over 20,000 adults aged 60 and above, DAO was defined by low handgrip strength and high waist circumference, with disability measured by difficulties in daily activities.
- - Diabetes, hypertension, and angina were identified as significant mediators in the relationship between DAO and disability, highlighting the need for further research on how addressing DAO could mitigate disability risks in older populations.
Background: Hypertension is one of the most important complications of chronic kidney disease (CKD) as it exacerbates disease progression in children. The aim of this study is to identify characteristics and factors associated with hypertension in children with CKD.
Methods: This is a cross-sectional study using baseline data from the 10-year ongoing cohort study named KNOW-PedCKD (Korean Cohort Study for Outcome in Patients with Pediatric Chronic Kidney Disease).
Article Synopsis
- The COH-FIT study is a large, multi-country survey aimed at identifying factors affecting wellbeing and mental health outcomes during the COVID-19 pandemic, involving a representative sample of 121,066 adults.
- Researchers analyzed both modifiable (like coping strategies and pre-pandemic stress) and non-modifiable factors (such as age, gender, and socioeconomic status), finding significant negative effects on wellbeing and psychopathology scores during the pandemic.
- The study identified 15 modifiable and 9 non-modifiable risk factors, alongside 13 modifiable and 3 non-modifiable protective factors, emphasizing the importance of social support and coping strategies in mental health outcomes.
Article Synopsis
- There is a lack of comprehensive international studies examining multidimensional mental health and wellbeing before and during the COVID-19 pandemic, particularly identifying at-risk groups and effective coping strategies.
- The COH-FIT survey, conducted from April 2020 to June 2022 in 30 languages, assessed changes in well-being and psychopathology among over 121,000 participants, revealing significant declines in mental health during the pandemic.
- Key findings indicated that certain demographics, such as young adults and people in low-income countries, were particularly affected, while coping strategies like exercise, internet use, and maintaining social contacts emerged as the most effective for managing stress.
We systematically reviewed observational and Mendelian randomization (MR) articles that evaluated the association between obesity and 17 gastrointestinal (GI) diseases to integrate causal and observational evidence. A total of 594 observational studies from 26 systematic reviews and meta-analyses and nine MR articles were included. For every 5 kg/m increase in body mass index (BMI), there was an increased risk of GI diseases ranging from 2% for rectal cancer (relative risk [RR]: 1.
View Article and Find Full Text PDFBackground: Knee osteoarthritis (KOA) is a widespread chronic condition. Depression frequently occurs among patients with KOA. The objective of this meta-analysis was to identify risk factors associated with comorbid depression in patients with KOA.
View Article and Find Full Text PDFWe investigated the association between sedentary behavior (SB) and wish to die (WTD; i.e., feeling that one would be better off dead or wishing for one's own death), and the extent to which this can be explained by sleep problems, depression, anxiety, loneliness, perceived stress, and social network in a nationally representative sample of adults aged ≥50 years from Ireland.
View Article and Find Full Text PDFArticle Synopsis
- A study in South Korea analyzed over 3 million infants to investigate the impact of antibiotic exposure during fetal and early postnatal periods on childhood neuropsychiatric disorders.
- Results indicated that both prenatal and postnatal antibiotic exposure were linked to a higher risk of disorders, with the strongest effects seen when exposure occurred during both periods.
- Specific conditions affected included intellectual disability, ADHD, anxiety, and autism, leading researchers to suggest that doctors weigh long-term risks when prescribing antibiotics to young children.
Purpose: Zoledronic acid can inhibit the activity of osteoclasts, and thus, may slow or inhibit bone loss. The purpose of this study was to systematically evaluate the efficacy and safety of zoledronic acid in the treatment of osteoporosis.
Methods: Four databases, PubMed, Embase, Cochrane Library, and Web of Science, were systematically searched up to December 26, 2022.
Article Synopsis
- This study investigates the risks of cardiovascular and cerebrovascular adverse events associated with intravitreal anti-VEGF treatments such as aflibercept, bevacizumab, brolucizumab, and ranibizumab, utilizing data from the WHO's VigiBase database spanning from 2004 to 2023.!* -
- Analysis revealed a significant increase in reports of myocardial infarction, hypertension, and various cerebrovascular incidents like cerebral infarction among those treated with anti-VEGF medications compared to the broader database of drug-related adverse events.!* -
- The findings suggest that aflibercept may lead to lower reporting rates of cardiovascular complications compared to ranibizumab, highlighting the importance of
Background: We aimed to systematically review meta-analyses on the link between attention-deficit/hyperactivity disorder (ADHD) and a broad range of psychiatric, physical, and behavioral health conditions (PROSPERO; no.CRD42023448907).
Results: We identified 22 meta-analyses that included 544 primary studies, covering 76 unique conditions in over 234 million participants across 36 countries and six continents.
Article Synopsis
- The study systematically reviewed and analyzed randomized controlled trials comparing unicompartmental knee arthroplasty (UKA) and total knee arthroplasty (TKA) for treating unicompartmental knee osteoarthritis (KOA).
- It included 13 publications with a total of 683 patients for each procedure, finding that UKA generally resulted in better knee recovery, function, less pain, and improved health status compared to TKA, but these differences were not clinically significant.
- UKA also had fewer complications and shorter hospital stays, but there were no significant differences in ranges of motion, revision rates, operation time, or patient satisfaction between the two procedures.
Article Synopsis
- - The study examined the link between SARS-CoV-2 infection and both short- and long-term neuropsychiatric issues using large cohorts from Korea and Japan, finding elevated risks compared to general population groups and those with other respiratory infections.
- - A variety of neuropsychiatric conditions, such as cognitive deficits, anxiety disorders, and mood disorders, showed notably increased long-term risk after infection, particularly influenced by the severity of COVID-19 and vaccination status.
- - The heightened risk for neuropsychiatric problems was most significant within the first six months post-infection, remaining relevant for about a year in Korea and longer in Japan, with findings consistent across both cohorts, adding to the knowledge on long COVID and its diverse impacts.*
Introduction: Observational studies are fraught with several biases including reverse causation and residual confounding. Overview of reviews of observational studies (ie, umbrella reviews) synthesise systematic reviews with or without meta-analyses of cross-sectional, case-control and cohort studies, and may also aid in the grading of the credibility of reported associations. The number of published umbrella reviews has been increasing.
View Article and Find Full Text PDFBackground: Cataracts may increase risk for falls but studies on this topic from low- and middle-income countries (LMICs) are scarce. Therefore, we examined the cross-sectional association between self-reported visual symptoms (suggesting cataract) and self-reported injurious falls in nationally representative samples of adults aged ≥ 65 years from five LMICs (China, Ghana, India, Mexico, and Russia).
Methods: Data from the WHO Study on global AGEing and adult health (SAGE) were analysed.
Background: Sedentary behavior, or time spent sitting, may increase risk for dynapenic abdominal obesity (DAO), but there are currently no studies on this topic.
Aims: Therefore, we investigated the association between sedentary behaviour and DAO in a nationally representative sample of older adults from six low- and middle-income countries.
Methods: Cross-sectional data from the Study on Global AGEing and Adult Health were analysed.
We provide here the first bottom-up review of the lived experience of mental disorders in adolescents co-designed, co-conducted and co-written by experts by experience and academics. We screened first-person accounts within and outside the medical field, and discussed them in collaborative workshops involving numerous experts by experience - representing different genders, ethnic and cultural backgrounds, and continents - and their family members and carers. Subsequently, the material was enriched by phenomenologically informed perspectives and shared with all collaborators.
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- The study aimed to explore the link between prenatal opioid exposure and the risk of neuropsychiatric disorders in children, utilizing a large birth cohort from South Korea.
- It analyzed data from over 3 million infants born between 2010 and 2017 and tracked their health outcomes until the end of 2020, identifying those diagnosed with mental and behavioral disorders.
- Results indicated a slight increased risk of neuropsychiatric disorders for infants with prenatal opioid exposure, but no significant association was found when comparing siblings, suggesting the need for further research.
Background: There are only preliminary studies examining the associations of postnatal antibiotic exposure with food allergy in childhood, and the effect of antibiotic exposure in utero has not been resolved. Thus, we aimed to investigate the effect of prenatal and postnatal antibiotic exposure on the risk of food allergy in childhood.
Methods: Using the nationwide birth cohort in South Korea, all 3,163,206 infants (pairing mother; n = 2,322,735) born in South Korea between 2010 and 2017 were included in the analysis.