Publications by Jae Hark Ryu

Publications by authors named "Jae Hark Ryu"

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Synthesis and cytotoxicity of new 3-alkyl-1-(1-methyl-2-phenylethyl)ureas related to ceramide.

Sejin Lim Jae Hark Ryu Chaeuk Im Chul Bu Yim

Arch Pharm Res

April 2003

A series of new 3-alkyl-1-(1-methyl-2-phenylethyl)ureas related to ceramide was synthesized and evaluated for their in vitro cytotoxic activity against five human tumor cell lines. The urea analogue (2b) of B13 showed comparable or slightly more potent cytotoxic activity as compared to B13, indicating that urea does appear to serve as a bioisostere of amide.

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