Publications by authors named "Jae Hak Moon"

Aphids are a major problem in agriculture, horticulture, and forestry by feeding on leaves and stems, causing discoloration, leaf curling, yellowing, and stunted growth. Although urushiol, a phenolic compound containing a catechol structure, is known for its antioxidant and anticancer properties, using small molecules to control aphids via catechol-mediated mechanisms is poorly understood. In this study, we investigated the effects of 3-methylcatechol (3-MC) on Myzus persicae fecundity.

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infections are a major cause of gastrointestinal disorders, including gastric ulcers, gastritis, and gastric cancer. Triple therapy, using two antibiotics and a proton pump inhibitor, is recommended for the treatment of infections. However, antibiotic resistance in is an emerging issue.

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This study aimed to develop improved multi-component beads with controlled, sustained delivery of antibiotics, such as gentamicin (GM). Antibiotic-loaded beads with rapid-release and the sustained-release system can be used for bone restoration. Single and multi-component beads were prepared by gelation using various combinations of chitosan and calcium chloride as cationic components and alginate and citric acid as anions.

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Glioblastoma (GBM) is one of the most dangerous brain tumors in humans. The median survival of patients with GBM is <18 months. Glioma stem-like cells (GSCs), a small subpopulation of cells with stem cell-like characteristics found within GBM, are regarded as the main cause of GBM malignancy.

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A gene encoding a laccase responsible for chartreuse onion bulb color was identified. Markers tagging this gene showed perfect linkage with bulb colors among diverse germplasm. To identify a casual gene for the G locus determining chartreuse bulb color in onion (Allium cepa L.

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Aphids, the major insect pests of agricultural crops, reproduce sexually and asexually depending upon environmental factors such as the photoperiod and temperature. Nuclear receptors, a unique family of ligand-dependent transcription factors, control insect development and growth including morphogenesis, molting, and metamorphosis. However, the structural features and biological functions of the aphid estrogen-related receptor (ERR) are largely unknown.

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We previously reported that 3-pentylcatechol (PC), a synthetic non-allergenic urushiol derivative, inhibited the growth of in an in vitro assay using nutrient agar and broth. In this study, we aimed to investigate the in vivo antimicrobial activity of PC against growing in the stomach mucous membrane. Four-week-old male C57BL/6 mice (n = 4) were orally inoculated with Sydney Strain-1 (SS-1) for 8 weeks.

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The present work describes the feasibility of coffee residue extracts as cryoprotective agents in the storage stability of freeze-dried lactic acid bacteria. Coffee residue extracts were extracted from coffee residue, produced after coffee extraction for coffee powder and instant coffee preparation, using an autoclave. Leuconostoc mesenteroides WiKim32 was selected to evaluate the ability of coffee residue extracts to protect bacteria during freeze-dried storage.

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Eighteen compounds including new caryophyllene-type sesquiterpene and flavonol tetraglycoside were purified and isolated from sword beans (). Two new compounds, (,1,7,9)-7-hydroxy-11,11-dimethyl-8-methylenebicyclo[7.2.

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Urushiols are important active compounds found in the sap of the lacquer tree ( Stokes). Recently, various biological effects of urushiols, such as antioxidant, antimicrobial, and anticancer activities, have been reported. However, urushiols can also induce skin allergies.

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Twenty compounds, including a new lignan amide, were isolated from the aerial parts of New Zealand spinach, (Pall.) Kuntze, which is an edible halophyte. These compounds were identified by mass spectrometry and nuclear magnetic resonance experiments to be -2,3-dihydroxy-3-(3,4-dihydroxyphenol)tyramine (new compound), methyl 4-hydroxybenzoate, syringaldehyde, ethyl 4-hydroxybenzoate, 3,4-dihydroxybenzoic acid, 2,3-dihydroxybenzoic acid, coniferyl alcohol, methyl caffeoate, - and -coumaroyl-β-d-glucopyranosides, - and -feruloyl-β-d-glucopyranosides, caffeic acid, staphylionoside E, canabiside D, apocyanol A, megastima-5,7-diene-3,4,9-triol, 1--oleoyl-3--β-d-galactopyranosyl--glycerol, 5,5'-dimethyl-lariciresinol, and kaempferol 3--β-d-glucopyranoside.

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Urushiols are amphipathic compounds found in Stokes that exhibit various biological activities. However, their practical use is very restricted due to their contact dermatitis-inducing property. Therefore, we applied the ionization method to remove the allergenic properties of the urushiols and to increase their usability.

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Six new 8---hydroxybenzylflavonol glycosides were isolated from a hot water extract of pumpkin ( Duch.) tendril and elucidated as 8---hydroxybenzylquercetin 3--rutinoside, 8---hydroxybenzoylquercetin 3--β-D-glucopyranoside, 8---hydroxybenzylkaempferol 3--(α-L-rhamnopyranosyl(1→6)-β-D-galactopyranoside, 8---hydroxybenzoylkaempferol 3--rutinoside, 8---hydroxybenzylisorhamnetin 3--rutinoside, and 8---hydroxybenzylisorhamnetin 3--(α-L-rhamnopyranosyl(1→6)-β-D-galactopyranoside. Their chemical structures were determined using nuclear magnetic resonance (NMR) and electrospray ionization-mass spectrometer (ESIMS) analyses.

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Catechins in green tea are well-known to be effective in reducing the risk of obesity. The purpose of this study was to elucidate the effects of catechins present in green tea on adipocyte differentiation and mature adipocyte metabolism. Treatment of 3T3-L1 mouse adipocyte during differentiation adipocytes with (-)-epigallocatechin (EGC) and gallic acid (GA) resulted in dose-dependent inhibition of adipogenesis.

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Three new decenynol glucosides were isolated from the aerial parts of . Their structures were determined to be 6,8-decadien-4-yn-ol 1--β-d-glucopyranoside, 6,8-decadien-4-yn-ol 1--β-d-glucopyranoside, and 6-decen-4-yn-ol 1--β-d-glucopyranoside based on extensive spectroscopic (NMR and MS) analysis. [Formula: see text].

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Scope: Obesity and diabetes are major public health problems and are emerging as pandemics. Considerable evidence suggests that pear fruit consumption is associated with a lower risk of obesity-related complications. Thus, the present study is conducted to investigate the therapeutic potential of pear extract (PE) for reversing obesity and associated metabolic complications in high-fat diet-induced obese mice.

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Nineteen compounds including one new flavanone were isolated from the juice of aged common sage exudate with sugar (ACSE). The isolated compounds were identified by NMR and MS analyses as levodopa methyl ester (), 3,4-dihydroxybenzoic acid (), ()-8-hydroxy-4-hydroxy-phenylpropanoic acid (), 4-hydroxybenzoic acid ethyl ester (), -caffeic acid (), -caffeic acid (), esculetin (), ()-8-hydroxy-3,4-dihydroxy-phenylpropanoic acid ethyl ester (), -rosmarinic acid (), -rosmarinic acid (), -rosmarinic acid methyl ester (), 6-methoxy-7,8,3',5'-tetrahydroxyflavanone (), nepetin (), -caffeic acid ethyl ester (), luteolin (), -caffeic acid ethyl ester (), 6-methoxynaringenin (), 1α-acetoxy-2-oxo-eudesman-3,7(11)-dien-8β,12-olide (), and hispidulin (). Compound was isolated for the first time from nature and seven compounds (, , , , , , and ) were newly identified from common sage.

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Five proanthocyanidins, two B-type dimers and three A-type trimers, were purified and isolated from the fruit peels of Nakai cv. Chuhwangbae. The isolated compounds were identified as (-)-epicatechin gallate-(4β → 8)-(-)-epicatechin (Hahashi et al.

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The aim of the current study was to describe the role and mechanism of Bacillus amyloliquefaciens Y1 against the root-knot nematode, Meloidogyne incognita, under in vitro and in vivo conditions. Initially, the exposure of the bacterial culture supernatant and crude extract of Y1 to M. incognita significantly inhibited the hatching of eggs and caused the mortality of second-stage juveniles (J2), with these inhibitory effects depending on the length of incubation time and concentration of the treatment.

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The natural, phenolic lipid urushiol exhibits both antioxidant and anticancer activities; however, its biological activity on hepatocellular carcinoma (HCC) has not been previously investigated. Here, we demonstrate that an urushiol derivative, 3-decylcatechol (DC), induces human HCC Huh7 cell death by induction of autophagy. DC initiates the autophagic process by activation of the mammalian target of rapamycin signaling pathway via Unc-51-like autophagy activating kinase 1, leading to autophagosome formation.

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Despite the critical role of melanin in the protection of skin against UV radiation, excess production of melanin can lead to hyperpigmentation and skin cancer. Pear fruits are often used in traditional medicine for the treatment of melasma; therefore, we investigated the effects of pear extract (PE) and its component, protocatechuic acid (PCA), on melanogenesis in mouse melanoma cells. We found that PE and PCA significantly suppressed melanin content and cellular tyrosinase activity through a decrease in the expression of melanogenic enzymes and microphthalmia-associated transcription factor () in α-melanocyte stimulating hormone-stimulated mouse melanoma cells.

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In this study, we isolated Bacillus licheniformis MH48 from rhizosphere soil and demonstrated that this strain shows significant antifungal activity against Rhizoctonia solani, Colletotrichum gloeosporioides, and Phytophthora capsici. Our results showed that a 50% concentration of bacterial cell-free culture filtrate of B. licheniformis MH48 shows strong activity against fungal pathogens.

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Malaxinic acid (MA) is a phenolic acid compound, found mainly in pear fruits (Pyrus pyrifolia N.), that is isoprenylated on the C-3 position of benzoic acid. Recently, the effects of prenylated phenolics on health have received much interest owing to their reported potent beneficial biological effects.

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Rhizoctonia solani is the cause of substantial economic loss in many crops. The aim of this study is to investigate biocontrol potential of Bacillus sp. L60 against R.

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