Publications by authors named "Jae H Cho"

Study Design: Retrospective cohort study.

Objective: To (1) determine whether preoperative neck pain improves after laminoplasty for cervical myelopathy and identify factors that could predict improvements in neck pain.

Methods: A total of 88 patients with preoperative neck pain visual analogue scale (VAS) of ≥4, who underwent laminoplasty for cervical myelopathy, and were followed-up for >2 years were retrospectively reviewed.

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Despite significant research progress, tumor heterogeneity remains elusive, and its complexity poses a barrier to anticancer drug discovery and cancer treatment. Response to the same drug varies across patients, and the timing of treatment is an important factor in determining prognosis. Therefore, development of patient-specific preclinical models that can predict a patient's drug response within a short period is imperative.

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Background: Microbial profiles in patients with chronic obstructive pulmonary disease (COPD) provide insights for predicting, preventing, and treating exacerbations. This study aimed to analyze the impact of microbial diversity and spectrum on COPD exacerbation.

Methods: From November 1, 2018, to May 31, 2023, we prospectively enrolled patients with stable disease (SD) and exacerbation of COPD (ECOPD).

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Ursodeoxycholic acid (UDCA), chenodeoxycholic acid (CDCA) plus UDCA (C&U), and terpene are widely administered to prevent common bile duct (CBD) stone recurrence and dissolve gallbladder (GB) stones. We evaluated and compared the combined effects of these agents on CBD stone recurrence and GB stone resolution. This study included patients who underwent endoscopic retrograde cholangiopancreatography (ERCP) at six referral centers, retrospectively.

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This study aimed to identify risk factors associated with mechanical failure in patients undergoing spinal instrumentation without fusion for metastatic spinal tumors. We retrospectively evaluated data from 220 patients with spinal tumors who underwent instrumentation without fusion. Propensity scores were used to match preoperative variables, resulting in the inclusion of 24 patients in the failure group (F group) and 72 in the non-failure group (non-F group).

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Background: Deep vein thrombosis (DVT) is a common complication in orthopedic surgery and has the potential to lead to fatal complications such as pulmonary thromboembolism. However, the precise incidence and risk factors for DVT in the foot and ankle fields remain unclear. This study aimed to analyze the prevalence of DVT and identify its risk factors after foot and ankle surgery.

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Background Context: Much controversy exists about whether posterior longitudinal ligament (PLL) resection should be performed during cervical artificial disc replacement (ADR). The PLL can be resected or preserved during the ADR procedure based on the shape and location of the compressive pathology. However, unlike fusion operations, the outcomes of ADR may be affected by PLL resection since segmental motion is preserved with ADR and the PLL restricts flexion of the segment.

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Article Synopsis
  • Cervical myelopathy, a condition affecting the spinal cord in the neck, is commonly treated with either atlantoaxial fusion (AAF) or occipitocervical fusion (OCF), though there hasn't been a comprehensive study comparing their outcomes.
  • The goal of this research was to evaluate and compare the clinical and radiological results of AAF versus OCF over a minimum follow-up period of 2 years, involving 64 patients.
  • Results indicated that while both surgical techniques had similar overall outcomes in terms of neck pain and disability scores, patients who underwent OCF experienced significantly greater declines in lifting function and neck range of motion compared to the AAF group after the surgery.
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: Allergic rhinitis (AR) is quite common and sometimes it requires systemic steroids and can be accompanied by coronavirus disease-2019 (COVID-19), rhinosinusitis, or asthma. We aimed to determine the comparative effect of different types of AR medications on clinical prognosis in real-world settings. : We used national claims data provided by the National Health Insurance Service in the Republic of Korea.

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: Endobiliary brushing is usually performed in the diagnosis of indeterminate biliary strictures; however, in this setting, brush cytology is limited by a low diagnostic yield and sensitivity. Here, we compared the catheter flushing method (CFM) with the conventional cytologic method (CCM) in terms of cellularity and diagnostic performance. : Endobiliary brushings were obtained during endoscopic retrograde cholangiopancreatography (ERCP) from patients with biliary strictures enrolled at six tertiary hospitals.

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  • High-resolution chest CT scans are essential for diagnosing Birt-Hogg-Dubé syndrome (BHD) and this study investigates how lung cysts in BHD differ from those in other cystic lung diseases.
  • In a retrospective analysis of 52,823 patients, 301 were identified with multiple lung cysts, with 24 (8%) diagnosed with BHD; most BHD patients showed bilateral cysts and larger sizes compared to other conditions.
  • The study established a predictive model with high sensitivity (95.83%) and specificity (81.22%) to identify BHD based on characteristics like cyst location, size, and diversity, aiding in the diagnosis of previously undetected cases.
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  • The study aimed to identify risk factors for local recurrence after surgery in patients with metastatic spinal cord compression (MSCC), as this had not been well researched before.
  • A retrospective analysis of 304 patients revealed that local recurrence occurred in 16.4% of cases, with higher rates linked to certain surgical methods, tumor types, and the presence of multiple metastases or pathologic fractures.
  • Key findings indicated that decompression alone had a significantly higher recurrence rate compared to other surgical techniques, and factors like renal cell carcinoma, extensive spinal metastasis, and smoking were also associated with higher local recurrence risk.
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  • ISG15 modification (ISGylation) is important for immune defense against viral infections like SARS-CoV-2 and helps boost innate immunity by modifying signaling proteins.
  • This study examines whether SARS-CoV-2 proteins can be ISGylated, identifying the nucleocapsid (N) protein as a target with crucial modification sites affecting its function.
  • It was found that ISGylation inhibits N protein dimerization and enhances susceptibility to immune responses, while the virus's PLpro protein can remove the ISG15 modification, countering the antiviral effects.
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Study Objectives: The use of sleep tracking devices is increasing as people become more aware of the importance of sleep and interested in monitoring their patterns. With many devices on the market, we conducted a meta-analysis comparing sleep-scoring data from consumer wrist-worn sleep tracking devices with polysomnography to validate the accuracy of devices.

Methods: We retrieved studies from the databases of SCOPUS, EMBASE, Cochrane Library, PubMed, Web of Science, and KoreaMed, and OVID Medline up to March 2024.

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Enhanced recovery after surgery (ERAS) protocols optimize perioperative care and improve recovery. This study evaluated the effectiveness of ERAS in one- or two-level posterior lumbar fusion surgeries, focusing on perioperative medication use, pain management, and functional outcomes. Eighty-eight patients undergoing lumbar fusion surgery between March 2021 and February 2022 were allocated into pre-ERAS ( = 41) and post-ERAS (n = 47) groups.

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Objective: Cord compression by the ligamentum flavum (CCLF) has been reported to adversely affect the clinical outcomes of anterior cervical discectomy and fusion (ACDF). While indirect decompression does occur for foraminal stenosis with ACDF, whether ACDF could improve CCLF with the distraction of disc space remains unclear. This study aimed to identify 1) whether indirect decompression occurs for CCLF with ACDF, and 2) risk factors that hinder the improvement of CCLF.

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Background/objectives: Early enteral feeding is crucial in acute pancreatitis (AP) to preserve the intestinal mucosa, prevent bacterial overgrowth, and prevent progression to pancreatic necrosis, multi-organ failure, and death. However, the optimal early diet remains unclear. This study compared an oral carbohydrate solution (OCS) diet versus a conventional diet (CD) in patients with AP.

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Article Synopsis
  • This study is a retrospective cohort analysis examining the use of a technique called guttering during anterior cervical discectomy and fusion (ACDF) in patients with cervical myelopathy.
  • The main goal was to see if guttering could effectively decompress retro-corporeal pathologies that traditional methods couldn't address, comparing outcomes between patients who underwent guttering and those who did not.
  • Findings showed no significant differences in fusion rates, pain levels, or neck disability after one year between the two groups, indicating that guttering could safely enhance the surgical approach without increasing complications.
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Background: Approximately half of the patients with advanced pancreatic ductal adenocarcinoma (PDAC) receive subsequent lines of chemotherapy. Recently, the liposomal irinotecan (nal-IRI) plus 5-fluorouracil/leucovorin (5-FU/LV) regimen is recommended as subsequent lines of chemotherapy. However, little is known about the predictive factors for the nal-IRI + 5-FU/LV regimen, especially in patients with previous irinotecan (IRI) exposure.

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Background Context: Anterior cervical discectomy and fusion (ACDF) combined with uncinate process resection and laminoplasty combined with foraminotomy (LPF) have been used to achieve cervical cord and root decompression in patients with combined cervical myeloradiculopathy (CMR).

Purpose: To compare the clinical and radiographic outcomes of ACDF with those of LPF for the treatment of CMR.

Study Design/setting: Propensity score-matched retrospective cohort study.

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Study Design: Retrospective cohort study.

Objective: To clarify whether clinical outcomes of anterior cervical discectomy and fusion (ACDF), is affected by presence of spinal canal-cord mismatch (SCCM).

Summary Of Background Data: SCCM is considered a factor that would moderately influence surgeons to perform posterior surgery since it could widen the spinal canal, while an anterior approach could only remove degenerative pathologies grown into the spinal canal.

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Objective: Nonunion and significant subsidence after anterior cervical discectomy and fusion (ACDF) are associated with poor clinical outcomes, which occasionally lead to revision surgery. Allograft and polyetheretherketone (PEEK) cages are the two most commonly used interbody spacer devices for ACDF. Although studies have been conducted to compare the efficacies of these two interbody materials, the question remains regarding the superiority of one over the other.

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Background: Encountering individuals sensitized to both inhalant and food allergens is challenging in clinical practice. Despite its rarity, studies have documented cross-sensitization between these allergens. However, the extent, diversity, and age-related variations of this phenomenon remain unclear.

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