Publications by authors named "Jae Chol Lee"
Background: EGFR genotyping in pulmonary adenocarcinoma patients who develop pleural effusions is mostly performed using cytology or cell block slides with low sensitivity. Liquid biopsy using the supernatant of pleural effusions may be more effective because they contain many components released by cancer cells. Extracellular vesicles (EVs) are known to carry oncogenic double-stranded DNA that is considered a notable biomarker.
View Article and Find Full Text PDFBackground: The NSCLC patients who experienced good clinical responses to an EGFR-TKI will inevitably develop acquired resistance. A great deal of research is being carried out to discover the molecular mechanisms underlying this resistance. In comparison, few studies have been conducted to find out about the clinical characteristics of acquired resistance in the patients who had responded to an EGFR-TKI.
View Article and Find Full Text PDFDetection and comparison of peptide nucleic acid-mediated real-time polymerase chain reaction clamping and direct gene sequencing for epidermal growth factor receptor mutations in patients with non-small cell lung cancer.
Lung Cancer
March 2012
Article Synopsis
- * This study analyzed 240 NSCLC patients using PNA-mediated real-time PCR clamping and direct DNA sequencing to evaluate EGFR mutation status and its link to treatment response.
- * Results showed that PNA-mediated PCR clamping identified more mutations (34.6%) than direct sequencing (26.3%), indicating it is a more sensitive and straightforward method for detecting EGFR mutations in clinical practice.