Antiviral immunity in chronic lymphocytic leukemia measured by anti-rubella antibody.

Background: Chronic lymphocytic leukemia (CLL), the most common form of adult leukemia in Caucasian populations, is characterized by a decrease in anti-infective immunity. Clinical evidence of antiviral immunity decrease is the reactivation of herpes virus in the form of skin lesions. In Europe, rubella infection is common and creates lifelong persistence of IgG antibodies.

The decrease in prolidase activity in myeloproliferative neoplasms.

Background: The development of bone marrow fibrosis is a severe complication in hematological diseases. The progress of bone marrow myelofibrosis is evaluated by a trephine examination and may be characterized by the biochemical markers of collagen turnover determination.

Objectives: Investigation of serum prolidase activity and biochemical markers of collagen metabolism in order to establish its role in the development of bone marrow fibrosis.

[Risk of bleeding in alimentary tract diseases].

The risk of bleeding from alimentary tract obtains the most frequently the upper part. The diseases predisposing are: ulceration of duodenum and stomach, erosions and other inflammatory lesions, than in succession oesophageal varices, erosions including Mallory-Weiss syndrome, stomach and oesophageal neoplasms. The bleedings from lower alimentary tract are about five times rare and caused by colonic diverticulosis, progress of colitis ulcerosa, Crohn syndrome, inflammatory processes after radiation and drugs using, cancers and polyps.

Proteolytic activity of clinical Candida albicans isolates in relation to genotype and strain source.

Proteolytic activity is regarded as one of the most important virulence factors of Candida albicans. Several authors recently demonstrated that some karyotypes and genotypes harbouring a group I self-splicing intron (CaLSU) located in the gene encoding the large rRNA subunit showed a high level of proteinase production. The aim of this study was to investigate the correlation between the level of proteinase production and the presence of the CaLSU intron in C.

[Leukemoid reaction with uncommonly high leucocytosis in the course of serious infection].

We present a case of 51-year old female patient with gastrointestinal perforation and septic shock leading to leukemoid reaction with WBC 155 x 109/l. Leukemoid reaction in neoplasms and infections can mimic chronic myelogenous leukaemia and is an important diagnostic problem.

[Amyloidosis in the course of multiple myeloma].

The amyloidoses are group of heterogeneous disorders, in which synthesized and secreted proteins, as a soluble molecules, are formed into insoluble, fibrillar tissue deposits, leading to organ dysfunction. Classification now is based on the chemical nature of the fibrillar component of the deposits. One of these is light-chain amyloidosis (AL).

[Leukemic reaction in the course of uterine myoma and urinary tract infection in pregnancy].

A leukaemic reaction is an increase of leukocytes count in peripheral blood between 20-50 G/l with significant percentage of immature white blood cells: metamyeloblasts, myelocytes and even myeloblasts in blood smear. The leukaemic reactions during cancers and many infections diseases, especially in the pregnancy, by their clinical symptoms and laboratory changes can imitate acute and chronic leukaemias. In this article we introduce a pregnant woman with the leukaemic reaction with leucocyte count 51 G/l and a presence of immature white blood cells with myeloblasts in peripheral blood smear.