The dark side of stemness - the role of hematopoietic stem cells in development of blood malignancies.

Hematopoietic stem cells (HSCs) produce all blood cells throughout the life of the organism. However, the high self-renewal and longevity of HSCs predispose them to accumulate mutations. The acquired mutations drive preleukemic clonal hematopoiesis, which is frequent among elderly people.

Anti-inflammatory effects of new human histamine H receptor ligands with flavonoid structure on BV-2 neuroinflammation.

Objective: Microglia play an important role in the neuroinflammation developed in response to various pathologies. In this study, we examined the anti-inflammatory effect of the new human histamine H receptor (HR) ligands with flavonoid structure in murine microglial BV-2 cells.

Material And Methods: The affinity of flavonoids (E243 -flavone and IIIa-IIIc-chalcones) for human HR was evaluated in the radioligand binding assay.