Transformative Results in Giant Pyoderma Gangrenosum with Dexamethasone-cyclophosphamide Pulse.

Pyoderma gangrenosum (PG) is a cutaneous ulcerative condition that can present in various forms, including ulcerative, bullous, pustular, vegetative, and peristomal. It often occurs and recurs in areas subjected to trauma due to the pathergy phenomenon, where irritation or injury triggers flare-ups. The condition typically begins as a painful erythematous lesion that rapidly progresses to a necrotic or blistering ulcer.

Dual Drug Loaded Topical Cubosomal Gel Against Candida Albicans: An In Vitro and In Vivo Proof of Concept.

Dual drug approaches are gaining research interest owing to the reduction of drug resistance and additive or synergistic effects in treating fungal infections caused by Candida albicans. The present study includes the combination of ketoconazole (KTC) and eugenol (EGN) co-embedded cubosomes (KTC-EGN-CBs) for the effective treatment of candidiasis.The bio-membrane-typical framework of the cubic phase in CBs can help retain both drugs leading to enhancement of antifungal activity.

Radially evolving spiral wave patterns in the Gierer-Meinhardt reaction-diffusion system.

Spiral wave formation in spatially extended systems is a fascinating phenomenon that has garnered significant attention in reaction-diffusion systems. In this study, we explore the emergence of spiral wave-like patterns in the Gierer-Meinhardt reaction-diffusion model. By employing a multiple-time scale perturbation technique, we derive amplitude equations that reveal the conditions for spiral wave formation.

Agreement and disagreement between diagnostic criteria for gestational diabetes and implications for clinical practice: A retrospective observational study.

Aims: To evaluate agreement/disagreement between eleven gestational diabetes (GDM) diagnostic criteria, including five used in current clinical practice globally.

Methods: Records of 353 pregnant women with oral glucose tolerance test performed after 20 weeks of gestation were retrospectively reviewed. The diagnosis of GDM was compared using the IADPSG, DIPSI, WHO 1999, CDA 2003 and 2013, NICE 2015, JSOG 1984, ADIPS 1998, ADA 2004, NZSSD 2004 and EASD 1996 criteria.

Advancing Pediatric Surgery with Indocyanine Green: Nonhepatobiliary Applications and Outcomes.

Aim: This prospective single-center study aimed to evaluate the nonhepatobiliary applications of indocyanine green fluorescence-guided surgery (ICG FGS) in pediatric patients, assessing its utility as an adjunct for intraoperative imaging.

Materials And Methods: Over a 30-month period from January 2021 to July 2023, pediatric patients undergoing various surgical procedures, excluding hepatobiliary cases, were included in the study. ICG (Aurogreen™) was administered intravenously or directly injected in tissue, and fluorescence imaging was conducted using specialized equipment (KARL STORZ GmbH and Co.

Assessing Cephalometric Changes in Deep Bite Correction: An Analysis of Class II Division 1 Orthodontic Patients Treated with the Reverse Curve of Spee Archwire.

Objective: This study aimed to analyze cephalometric changes associated with deep bite correction using the Reverse Curve of Spee (RCS) archwire in class II division 1orthodontic patients.

Methods: A total of 168 orthodontic patients (aged 12-25 years) with diagnosed deep bite malocclusion underwent deep bite correction using RCS archwires between January 2019 and December 2020. Cephalometric radiographs were taken at various time points to assess skeletal and dental changes.

The Effect of Different Obturation Techniques on the Sealing Ability of Root Canal Filling Materials.

Background: The performance of root canal filling materials in sealing is crucial for the effectiveness of endodontic procedures as it prevents the escape of microorganisms and guarantees the durability of the treatment.

Materials And Methods: The present investigation included the preparation of 90 human single-rooted teeth using a standardized process. These teeth were then randomly separated into three groups (n = 30) according to the obturation technique: Group A (Lateral Compaction), Group B (Thermafil), and Group C (Continuous Wave of Condensation).

Impact of Fixed Orthodontic Appliances on Blood Count and High-Sensitivity C-Reactive Protein Levels.

Background: Fixed orthodontic appliances are widely used in dental practice to correct malocclusions and improving oral health. However, their impact on systemic inflammation and hematological parameters remains under-explored.

Materials And Methods: A cohort of 60 patients, aged 12 -30 years, undergoing fixed orthodontic treatment, were enrolled in the study.

Surgical and psychosocial factors related to Pediatric Medical Traumatic Stress (PMTS) in children following surgery: a follow-up study.

Introduction: Surgical procedures in children involve significant psychological traumatic stress leading to the development of psychologic distress and dysfunction after surgery. Pediatric medical traumatic stress (PMTS) ensues from negative medical experiences which is a trauma that can have a devastating effect on children and their families. Awareness and early identification are important to provide psychological intervention at the correct time.

Molecular and therapeutic insight into ER stress signalling in NSCLC.

Endoplasmic Reticulum (ER) stress is intricately involved in cancer development, progression and response to chemotherapy. ER stress related genes might play an important role in predicting the prognosis in lung adenocarcinoma patients and may be manipulated to improve the treatment outcome and overall survival rate. In this review, we analysed the contribution of the three major ER stress pathways-IRE1, ATF6, and PERK-in lung cancer pathogenesis modulation of tumour microenvironment (TME) and processes as metastasis, angiogenesis, apoptosis and N-glycosylation.

Antifungal activity of 2-adamantylamine hydrochloride on and .

Increased virulence and drug resistance in species of resulted in reduced disease control and further demand the development of potent antifungal drugs. The repurposing of non-antifungal drugs and combination therapy has become an attractive alternative to counter the emerging drug resistance and toxicity of existing antifungal drugs against and non-albicans species. This study aimed to accelerate antifungal drug development process by drug repurposing approach.

Understanding exposure risk using soil testing and GIS around an abandoned asbestos mine.

Abandoned asbestos mines are a potential source of environmental contamination and exposure for nearby residents. The asbestos exposure risk may persist even after the cessation of mining activity if the mine is not properly closed. One such abandoned mine is at Roro Hills in the Jharkhand state of India.

Experimental approaches to evaluate solid lipid nanoparticle-based drug delivery systems.

Solid lipid nanoparticles (SLNs) are potential drug carriers due to the several advantages they offer. The physicochemical stability of lipid carriers varies significantly due to their diverse compositions and structures. Appropriate analytical methods are required for the complete characterization of SLNs.

Antibody responses against influenza A decline with successive years of annual influenza vaccination.

Influenza vaccine effectiveness and immunogenicity can be compromised with repeated vaccination. We assessed immunological markers in a cohort of healthcare workers (HCW) from six public hospitals around Australia during 2020-2021. Sera were collected pre-vaccination and ~14 and ~180 days post-vaccination and assessed in haemagglutination inhibition assay against egg-grown vaccine and equivalent cell-grown viruses.

Regioisomeric π-Extended Nanographene with Long-Lived Phosphorescence Afterglow.

The cutouts of graphene sheets, particularly those with a nonplanar topology, present vast opportunities for advancement. Even a slight deviation from the planar structure can lead to intriguing (chiro)optical features for helically twisted nanographenes. In this context, we introduce two regioisomeric π-extended nanographenes that exhibit distinct excited-state characteristics.

Safety of Adjunctive Intraarterial Tenecteplase Following Mechanical Thrombectomy: The ALLY Pilot Trial.

Background: Recent studies suggest that the use of adjunctive intraarterial alteplase after mechanical thrombectomy (MT) may improve outcomes; however, there are limited data on the use of intraarterial tenecteplase, a newer-generation lytic, in this acute ischemic stroke patient population. Here, we evaluate the use of intraarterial tenecteplase in the ALLY pilot study (Adjunctive Intraarterial Tenecteplase Following Mechanical Thrombectomy).

Methods: ALLY was a prospective, single-center, nonrandomized pilot study assessing the feasibility and safety of intraarterial tenecteplase up to 4.

Development, Pre-Clinical Safety, and Immune Profile of RENOVAC-A Dimer RBD-Based Anti-Coronavirus Subunit Vaccine.

The development of effective and safe vaccines and their timely delivery to the public play a crucial role in preventing and managing infectious diseases. Many vaccines have been produced and distributed globally to prevent COVID-19 infection. However, establishing effective vaccine development platforms and evaluating their safety and immunogenicity remains critical to increasing health security, especially in developing countries.

Solid dispersion of alectinib HCl: preclinical evaluation for improving bioavailability and establishing an IVIVC model.

Objective: Alectinib HCl (ALB-HCl) is a BCS class IV molecule with low solubility and low oral bioavailability. Owing to its low bioavailability, a high dose of ALB-HCl is recommended with food to meet clinical efficacy. Thus, there is a need for a delivery system to overcome the bioavailability concerns.

Indocyanine Green Fluorescence-Guided Surgery in Pediatric Hepatobiliary Procedures: A Feasibility Study for Improved Intraoperative Visualization.

Introduction:  Indocyanine green (ICG) fluorescence-guided surgery (FGS) is reported extensively in adult operations, but its safety and applications in pediatric populations remain to be comprehensively understood. The dose, administration protocols, and intraoperative imaging benefits in pediatric hepatobiliary operations are not clear.

Objectives:  This study aimed to identify the feasibility and applications of ICG FGS in hepatobiliary surgeries (for biliary atresia, choledochal cyst, and cholelithiasis) in children.

Zingerone effect against Candida albicans growth and biofilm production.

Background: The increasing resistance of Candida albicans biofilms underscores the urgent need for effective antifungals. This study evaluated the efficacy of zingerone and elucidated its mode of action against C. albicans ATCC 90028 and clinical isolate C1.

Geo-spatial analysis of acute ischemic stroke reperfusion treatment in India: An assessment of distribution and access to centers.

Background: Stroke is a leading cause of global mortality and disability, with a disproportionately high burden in low- and middle-income countries. Access to intravenous thrombolysis (IVT) and endovascular treatment (EVT) remains extremely limited.

Aims: We evaluated the spatial distribution and geographic accessibility of stroke centers in India.

HF-free low-temperature synthesis of MXene for electrochemical hydrogen production.

MXenes [two-dimensional (2D) transition-metal carbides, nitrides and carbonitrides] are gaining significant interest as alternative electrocatalysts for the hydrogen evolution reaction due to their excellent properties such as high electrical conductivity, large surface area and chemical stability. MXenes are traditionally synthesized using hydrofluoric acid (HF), which raises safety and environmental concerns due to its highly corrosive and toxic nature. HF introduces fluoride functional groups on the surface of MXenes, and these have been reported to have a detrimental effect on electrocatalysis.

Viral sequence determines HLA-E-restricted T cell recognition of hepatitis B surface antigen.

The non-polymorphic HLA-E molecule offers opportunities for new universal immunotherapeutic approaches to chronic infectious diseases. Chronic Hepatitis B virus (HBV) infection is driven in part by T cell dysfunction due to elevated levels of the HBV envelope (Env) protein hepatitis B surface antigen (HBsAg). Here we report the characterization of three genotypic variants of an HLA-E-binding HBsAg peptide, Env identified through bioinformatic predictions and verified by biochemical and cellular assays.