Publications by authors named "Jade Scheers"
Scaling up the manufacture of cell therapies can be complex and challenging. Maintaining critical quality attributes of the cell product during its final formulation and fill-finish into multiple containers can be especially difficult and laborious. Here, we tested the automated Finia™ Fill and Finish System to efficiently scale up the formulation and fill-finish of a T cell product, and then assessed cell quality and product consistency across different sub-lots filled during this expanded process.
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- Fenoterol and its derivatives can inhibit cell growth in astrocytoma cells via β(2)-adrenergic receptor stimulation, but their effects on different cell types, like hepatocarcinoma cells, are less understood.
- In HepG2 cells, β(2)-AR stimulation by fenoterol boosts cell growth, while a derivative, MNF, decreases growth and increases cell death, showing contrasting effects.
- The study reveals that MNF's action links β(2)-AR and cannabinoid receptors, suggesting MNF uniquely engages both pathways, marking it as a dual-action ligand.