Publications by authors named "Jade Mammi"
Article Synopsis
- - The study focuses on dysbetalipoproteinemia (DBL), a lipid disorder linked to cardiovascular disease risk, especially in individuals with the ε2ε2 genotype, and evaluates the effectiveness of nine different screening algorithms, including a new one developed by the researchers.
- - Patients were classified into three groups based on their genetic background and the diagnostic performance of the algorithms was assessed against a gold standard of specific triglyceride levels and genotypes.
- - The findings indicate that the "Hospices Civils de Lyon (HCL) algorithm" demonstrated superior diagnostic ability for detecting DBL in both ε2ε2 and rare variant carriers compared to other algorithms, highlighting the need for further investigation into the accuracy of these screening methods.
Mechanical stress is known to fuel several hallmarks of cancer, ranging from genome instability to uncontrolled proliferation or invasion. Cancer cells are constantly challenged by mechanical stresses not only in the primary tumour but also during metastasis. However, this latter has seldom been studied with regards to mechanobiology, in particular resistance to anoikis, a cell death programme triggered by loss of cell adhesion.
View Article and Find Full Text PDFGlioblastoma (GBM) is one of the cancers with the worst prognosis, despite huge efforts to understand its unusual heterogeneity and aggressiveness. This is mainly due to glioblastoma stem cells (GSCs), which are also responsible for the frequent tumor recurrence following surgery, chemotherapy or radiotherapy. In this study, we investigate the expression pattern of the anti-apoptotic BCL-xL protein in several GBM cell lines and the role it might play in GSC-enriched tumorspheres.
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