Publications by authors named "Jade A Steber"
Article Synopsis
- Environmental enrichment (EE) effectively improves neurobehavioral and cognitive functions following traumatic brain injury (TBI), but its preventative effects against TBI are uncertain.
- The study hypothesized that EE before TBI surgery would protect against deficits and suggest additional benefits if EE was provided both before and after the injury.
- Results showed that while pre-injury EE didn't provide a protective effect against TBI, rats with post-injury EE performed better in motor skills and cognitive tests compared to those without enrichment.
Cholinergic disruptions underlie attentional deficits following traumatic brain injury (TBI). Yet, drugs specifically targeting acetylcholinesterase (AChE) inhibition have yielded mixed outcomes. Therefore, we hypothesized that galantamine (GAL), a dual-action competitive AChE inhibitor and α7 nicotinic acetylcholine receptor (nAChR) positive allosteric modulator, provided chronically after injury, will attenuate TBI-induced deficits of sustained attention and enhance ACh efflux in the medial prefrontal cortex (mPFC), as assessed by microdialysis.
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