The study investigates how cocoa flavanols, particularly epicatechin (EPI), can help improve muscle function in patients with peripheral artery disease (PAD) by enhancing antioxidant defenses and reducing muscle damage.
In a clinical trial, participants consuming a cocoa-flavanol drink showed better walking performance and muscle health compared to those who received a placebo, with notable increases in key antioxidants linked to muscle repair.
Analysis revealed that cocoa flavanols activate Nrf2, a protein that boosts antioxidant production, which may protect against oxidative stress and improve mitochondrial function in muscle cells affected by PAD.