[Exposure of women to chemical solvents during work at chemical plants and its relation to various biochemical parameters].

The studies covered 211 women employed at a Technical Articles Plant in exposure to chemical solvents, such as: methyl alcohol, benzyl alcohol, methylene chloride, ethyl acetate, acetone, carbon tetrachloride, xylene, toluene, n-amyl acetate. The workplaces were ventilated and the concentrations of vapours did not exceed Threshold Limit Values (TLVs). Arithmetic means did not reveal any exposure to chemicals at particular plant divisions, which was also confirmed by the indices of admissible concentrations of chemicals or their metabolites in biological fluids (ABC--admissible biological concentrations).

Isoenzymes of N-acetyl-beta-D-glucosaminidase in urine of patients with acute renal failure after intoxication.

Activity of urinary N-acetyl-beta-D-glucosaminidase (NAG) was determined and basic clinical studies were carried out in oliguric, polyuric phases and restoration to health in patients with acute renal failure due to intoxication. At the same time, enzyme separation into isoenzymes A and B was achieved by column ion-exchange chromatography and by electrophoresis. This was done in urines from 9 patients and a control group of 10 persons who had no contact with toxic substances.

Isolation and some properties of zinc-containing proteins from human placenta.

Applying molecular filtration, the presence of two zinc-binding protein fractions in the human placenta was found. Their molecular weights were 47000 and 7900, respectively. A method for isolation of the high-molecular weight fraction from the placenta was elaborated.

[Concentration of heavy metals in pregnant women].

Copper, zinc, and lead concentrations were measured in two groups 72 pregnant women. Twenty-one of them, making up the control group, lived and worked in Wrocław. The other 51 women, the second group, had lived more than five years in Lubin-Polkowice and worked in the local non-ferrous metal plants.

Biochemical studies on populations with long- or short-term exposure to environmental pollution.

Three groups of populations were studied: I. living for about 10 years, II. living for about 3 years near copper smelteries, and III.

[Behavior of various serum and urinary peptidases in pregnancy].

The investigations were carried out on activities of leucinearylamidase (LAP) and (GGTP) gammaglutamyltranspeptidase in serum and urine of women with physiological and prolonged pregnancy. The results shown on pathological increase of LAP-activity in serum and increase excretion of both enzymes in to the urine during prolonged pregnancy. These findings may appear very important for the explain of pathomechanism of prolonged pregnancy and diagnostic purpose.

Investigations of the excretion of gamma-glutamyl-transpeptidase into the urine.

The excretion of the enzyme gamma-glutamyl-transpeptidase and its isoenzymes into the urine was investigated in patients with renal diseases and compared with the excretion of the enzymes leucine-aminopeptidase and lactate-dehydrogenase. In animal experiments an increased excretion of these enzymes was found after autotransplantation. Increased excretion of gamma-glutamyl-transpeptidase was also found in patients with glomerulonephritis and in the polyuric phase of acute tubular necrosis, but not in cases of pyelonephritis and in the oliguric phase of acute tubular necrosis.