Publications by authors named "Jacquie Malette Loredo"
Bioconjug Chem
September 2021
Article Synopsis
- Small peptides that bind specifically to CD8+ T cells show promise for diagnosing immune responses through molecular imaging.
- Researchers developed F-labeled peptides targeting human CD8α using a fast and efficient chemical process, achieving high radiochemical yield.
- The inclusion of a hydrophilic linker enhances the tracer's pharmacokinetics and improves image quality in PET imaging studies.
Article Synopsis
- The IL-17 cytokine family is important in various immune and autoimmune diseases, making it a key focus for diagnostics and therapies.
- Researchers developed specific ligands that can differentiate between human IL-17F and IL-17A by identifying unique epitopes on each protein.
- The study successfully created macrocyclic peptide binders with high selectivity and affinity for IL-17F and IL-17A, offering a method for targeting complex epitopes like those recognized by B cell receptors.
