Publications by authors named "Jacqui M Marzec"
Inflammation resolution in environmental pulmonary health and morbidity.
Toxicol Appl Pharmacol
August 2022
Article Synopsis
- * Environmental factors like pollutants and toxins can disrupt the body’s healing pathways, intensifying lung inflammation and possibly initiating diseases such as asthma and COPD.
- * Continuous exposure to harmful substances not only worsens lung function but also contributes to persistent inflammation, suggesting that managing environmental toxins is critical for respiratory health.
In this pilot work, we selected two inbred strains that respond well to endurance training (ET) (FVB/NJ, and SJL/J strains), and two strains that respond poorly (BALB/cByJ and NZW/LacJ), to determine the effect of a standardized ET treadmill program on mitochondrial and nuclear DNA (nucDNA) integrity, and mitochondrial DNA (mtDNA) copy number. DNA was isolated from plantaris muscles (n = 37) and a gene-specific quantitative PCR-based assay was used to measure DNA lesions and mtDNA copy number. Mean mtDNA lesions were not different within strains in the sedentary or exercise-trained states.
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- Researchers identified the transcription factor Nrf2 as a key gene linked to acute lung injury (ALI) using positional cloning in a mouse model.
- Nrf2 helps regulate protective enzymes against oxidative stress by binding to antioxidant response elements.
- A specific genetic variant, -617 A SNP, was linked to an increased risk of developing ALI in humans, particularly after major trauma, suggesting potential for identifying individuals at higher risk for this condition and similar oxidative stress-related diseases.