Publications by authors named "Jacques Sevestre"

is a protozoan parasite of the family Trypanosomatidae, transmitted by the bite of phlebotomine sand flies (Diptera: Psychodidae). It is responsible for human and canine leishmaniasis in countries bordering the Mediterranean basin. Here we describe a clinical case of human cutaneous leishmaniasis in a 76-year-old female patient living in Marseille.

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Bed bug has become a major public health pest worldwide. Infestation may result in numerous negative health effects. Homeless shelters are one of the most habitats that can be infested with bed bugs, a few studies have focused on bed bug infestations in these settings.

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Introduction: Arthropods are known to impair human health in various manners, acting as infectious disease vectors, or as simple nuisances. Even though considerable research is being produced in medical entomology, no reports on patient management in clinical entomology units are available in the literature.

Patients And Methods: We retrospectively surveyed all the records from patients having consulted in our outpatient clinical entomology unit in Nice University Hospital from 2012 to 2020.

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An increased incidence of invasive fungal infection was reported in SARS-CoV-2-infected patients hospitalised in the intensive care unit. However, the impact of COVID-19 on airway colonisation has not yet been assessed. This study aimed to test the impact of several factors on airway colonisation, including SARS-CoV-2 infection.

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Monitoring of tickborne diseases is critical for prevention and management. We analyzed 418 ticks removed from 359 patients during 2014-2021 in Marseille, France, for identification and bacteria detection. Using morphology, molecular methods, or matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, we identified 197 (47%) Ixodes, 136 (33%) Dermacentor, 67 (16%) Rhipicephalus, 8 (2%) Hyalomma, 6 (1%) Amblyomma, 2 (0.

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Article Synopsis
  • - Human bed bug infestations have increased globally, particularly in Africa, with two species affecting people, identified through morphology and gene sequencing, potentially enhanced by MALDI-TOF MS technology.
  • - This study analyzed immature bed bug stages collected in Nouakchott, Mauritania, using both morphological identification and MALDI-TOF MS, which successfully identified 35 out of 45 specimens at the species level.
  • - The findings indicate that MALDI-TOF MS is a reliable method for identifying bed bug species, including immature ones, and future research should expand on this method to include more specimens and developmental stages.
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Background: The French Riviera has been declared free of Lyme Borreliosis (LB) for years. Many patients are referred for presumed LB, sometimes with atypical clinical signs and/or doubtful serology, calling the diagnosis into question.

Methods: Patients were assessed for LB diagnosis, depending on clinical presentation, laboratory findings, and further examination by other medical professionals.

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Article Synopsis
  • Mediterranean spotted fever (MSF) is a tick-borne disease caused by the bacterium Rickettsia conorii, primarily spread by the brown dog tick, and mostly found in the Mediterranean region.
  • Symptoms of MSF typically include skin rash, high fever, and a specific sore (eschar) at the tick bite site, with varying severity from mild to potentially severe.
  • A case report highlights a patient who experienced isolated facial nerve paralysis as a rare complication of MSF, showing the disease can have unusual neurological effects.
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  • Lyme borreliosis is a tick-borne disease that is the most common vector-borne illness in the northern hemisphere, and a study was conducted in southeastern France to explore the presence of the Ixodes ricinus tick, typically thought absent in the Mediterranean region.
  • Researchers collected over 1200 ticks, with 70% identified as I. ricinus, and tested these ticks for various tick-borne bacteria, discovering Lyme disease-causing Borrelia and other pathogens like Borrelia miyamotoi and Rickettsia.
  • The findings indicate that the Alpes-Maritimes area has I. ricinus ticks that can carry Lyme disease and other bacteria, highlighting the importance for healthcare providers and outdoor enthusiasts to understand the
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Background: Malaria is a potentially lethal parasitic disease due to infection by Plasmodium parasites, transmitted by Anopheles mosquito vectors. Various preventative measures may be recommended for travellers who visit endemic areas. The diagnosis is generally evoked in the context of a febrile patient returning from an endemic zone.

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Arthropod vectors have historically been identified morphologically, and more recently using molecular biology methods. However, both of these methods are time-consuming and require specific expertise and equipment. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry, which has revolutionized the routine identification of microorganisms in clinical microbiology laboratories, was recently successfully applied to the identification of arthropod vectors.

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Background: We need an effective treatment to cure COVID-19 patients and to decrease virus carriage duration.

Methods: We conducted an uncontrolled, non-comparative, observational study in a cohort of 80 relatively mildly infected inpatients treated with a combination of hydroxychloroquine and azithromycin over a period of at least three days, with three main measurements: clinical outcome, contagiousness as assessed by PCR and culture, and length of stay in infectious disease unit (IDU).

Results: All patients improved clinically except one 86 year-old patient who died, and one 74 year-old patient still in intensive care.

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