Publications by authors named "Jacques Rollet"
Background: The high frequency of the cystic fibrosis (CF) transmembrane conductance regulator (CFTR) gene mutation p.Arg117His in patients with congenital bilateral absence of the vas deferens (CBAVD) and in newborns screened for CF has created a dilemma.
Methods: Phenotypic and genotypic data were retrospectively collected in 179 non-newborn French individuals carrying p.
Article Synopsis
- Hypogonadism affects 2-4 million men in the U.S., but only 5% receive treatment; testosterone replacement therapy improves sexual function, mood, and energy levels.
- The study evaluates the long-term safety and efficacy of the Testopatch, a transdermal testosterone delivery method, over a 6-year period for patients with primary or secondary hypogonadism.
- Results showed that Testopatch maintained stable testosterone levels without increasing prostate-specific antigen (PSA) concentrations or cancer risks, suggesting it is a safe treatment option for hypogonadal men.
Article Synopsis
- The study aimed to discover new mutations in the AURKC gene of patients with macrozoospermia and to explore the relationship between their genetic changes and observed phenotypes.
- Researchers discovered a new non-sense mutation, p.Y248*, which accounts for 13% of all mutant alleles, but found no phenotype differences compared to the previously known main mutation, c.144delC.
- The study involved 87 patients with primary infertility from multiple countries, where sperm analysis and extensive molecular testing of the AURKC gene were conducted to assess the mutations and their impacts.
Objectives: To study long-term efficacy and safety of a testosterone-in-adhesive matrix patch, delivering 4.8 mg of testosterone daily.
Methods: Randomized, open label, multicenter 1-year study.
Objective: To localize the different proteins involved in the executioner step of apoptosis in the human testicular tissue: effector caspases (3, 6, and 7), caspase inhibitors called inhibitor of apoptosis proteins (IAPs, such as XIAP), and IAP inhibitors such as Smac/DIABLO and to investigate XIAP and Smac expression and activation of caspase-3 in azoospermia.
Design: Retrospective study.
Setting: The Biology of Reproduction Center of Poissy and Inserm U407, France.
Reactive oxygen species (ROS) have a negative impact on sperm DNA, leading to the formation of oxidative products such as 8-oxo-7,8-dihydroxyguanosine. This compound causes fragmentation and, thus, has a mutagenic effect. Patient treatment with oral antioxidant vitamins is, therefore, standard practice for male infertility, in an attempt to decrease formation of ROS and improve fertility.
View Article and Find Full Text PDFPurpose: To determine if GV oocytes, collected at the time of ICSI, can be matured in vitro and rescued for therapeutic treatment. A patient for whom all the collected oocytes at the GV stage after a classical COH protocol were matured in vitro with GH.
Method: All the naked oocytes were matured in a culture medium (ISM2) containing 15% patient serum +1.
Objective: To study the correlation between genital phenotype and cystic fibrosis genotype in men lacking at least one vas deferens.
Design: Prospective study.
Setting: Institut Rhônalpin pour la Reproduction Humaine, Lyon-Bron, France.