Publications by authors named "Jacques Dermer"
Pathogenic ATM Variant-Harbouring Well-Differentiated Aggressive Type 1 Gastric Neuroendocrine Tumour with High-grade Features (G3 NET): a New Addition to the Clinical and Pathological Spectrum of Gastric Neuroendocrine Neoplasms.
Hussein Nassereddine Matthieu Chicaud Khedidja Rebah Nathalie Théou-Anton Anne Sautet Jacques Dermer
Endocr Pathol
December 2021
Article Synopsis
- Gastric type 1 neuroendocrine tumors are usually low-proliferation and have a favorable prognosis, but this case presents an aggressive grade 3 variant.
- The tumor had a high Ki-67 proliferation index of 30%, indicating its aggressive nature, and was linked to autoimmune gastritis.
- Genetic testing revealed a pathogenic mutation in the ATM gene, which may contribute to the tumor's growth and spread, ultimately leading to the patient's death after 6 years due to disease progression.