Publications by authors named "Jacques Brelet"
J Enzyme Inhib Med Chem
December 2002
Article Synopsis
- A series of N-substituted indole carboxamides were synthesized to evaluate their effectiveness as inflammation inhibitors, with only two compounds showing significant effects in reducing inflammation.
- The study revealed that incorporating alkyl chain spacers improved the efficacy of these compounds, particularly in the indolepropanamide sub-group.
- The most effective propanamides demonstrated potent anti-inflammatory properties in both oral and topical applications, with one compound showing up to 78% inhibition in a mouse ear swelling assay.
