Bcl-6 is the nexus transcription factor of T follicular helper cells via repressor-of-repressor circuits.

T follicular helper (T) cells are a distinct type of CD4 T cells that are essential for most antibody and B lymphocyte responses. T cell regulation and dysregulation is involved in a range of diseases. Bcl-6 is the lineage-defining transcription factor of T cells and its activity is essential for T cell differentiation and function.