Publications by authors named "Jacquelyn L Sikora"
Article Synopsis
- Wild-type transthyretin amyloidosis (ATTRwt) is a condition primarily affecting elderly Caucasian males, leading to heart issues from amyloid protein buildup, with unclear causes and no current diagnostic biomarkers.
- * A study of 108 ATTRwt patients compared to 118 matched controls identified 11 genetic variants, with three significantly linked to the disease, highlighting the complexity of genetic factors in ATTRwt progression.
- * Findings suggest that non-coding and coding variants may influence the age of onset and survival rates in ATTRwt, indicating the need for more research to understand their impact and potential for assessing disease risk.
Dimer exchange and cleavage specificity of the DNA damage response protein UmuD.
Biochim Biophys Acta
February 2013
The cellular response to DNA damage in Escherichia coli is controlled in part by the activity of the umuD gene products. The full-length dimeric UmuD(2) is the initial product that is expressed shortly after the induction of the SOS response and inhibits bacterial mutagenesis, allowing for error-free repair to occur. Over time, the slow auto-cleavage of UmuD(2) to UmuD'(2) promotes mutagenesis to ensure cell survival.
View Article and Find Full Text PDFThe homodimeric umuD gene products play key roles in regulating the cellular response to DNA damage in Escherichia coli. UmuD(2) is composed of 139-amino acid subunits and is up-regulated as part of the SOS response. Subsequently, damage-induced RecA·ssDNA nucleoprotein filaments mediate the slow self-cleavage of the N-terminal 24-amino acid arms yielding UmuD'(2).
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