High Inter-Patient Variability in Sepsis Evolution: A Hidden Markov Model Analysis.

Background: Severe sepsis and septic shock are common in the intensive care unit (ICU) and contribute significantly to cost and mortality. Early treatment is critical but is confounded by the difficulty of real-time diagnosis. This study uses hidden Markov models (HMMs) to examine whether the time evolution of sepsis can add diagnostic accuracy or value using a proven set of bio-signals.

Kernel density estimates for sepsis classification.

Objective: Severe sepsis is a leading cause of intensive care unit (ICU) admission, length of stay, mortality, and cost. systemic inflammatory response syndrome (SIRS) and organ failure due to infection define it, but also make it hard to diagnose. Early diagnosis reduces morbidity, mortality and cost, and diagnosis is often significantly delayed due to a lack of effective biomarkers.

A physiological Intensive Control Insulin-Nutrition-Glucose (ICING) model validated in critically ill patients.

Intensive insulin therapy (IIT) and tight glycaemic control (TGC), particularly in intensive care unit (ICU), are the subjects of increasing and controversial debate in recent years. Model-based TGC has shown potential in delivering safe and tight glycaemic management, all the while limiting hypoglycaemia. A comprehensive, more physiologically relevant Intensive Control Insulin-Nutrition-Glucose (ICING) model is presented and validated using data from critically ill patients.

Tight glycemic control in critical care--the leading role of insulin sensitivity and patient variability: a review and model-based analysis.

Tight glycemic control (TGC) has emerged as a major research focus in critical care due to its potential to simultaneously reduce both mortality and costs. However, repeating initial successful TGC trials that reduced mortality and other outcomes has proven difficult with more failures than successes. Hence, there has been growing debate over the necessity of TGC, its goals, the risk of severe hypoglycemia, and target cohorts.

Impact of glucocorticoids on insulin resistance in the critically ill.

Glucocorticoids (GCs) have been shown to reduce insulin sensitivity in healthy individuals. Widely used in critical care to treat a variety of inflammatory and allergic disorders, they may inadvertently exacerbate stress-hyperglycaemia. This research uses model-based methods to quantify the reduction in insulin sensitivity from GCs in critically ill patients, and thus their impact on glycaemic control.

Development of a model-based clinical sepsis biomarker for critically ill patients.

Sepsis occurs frequently in the intensive care unit (ICU) and is a leading cause of admission, mortality, and cost. Treatment guidelines recommend early intervention, however positive blood culture results may take up to 48 h. Insulin sensitivity (S(I)) is known to decrease with worsening condition and could thus be used to aid diagnosis.